*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : US5638000
CHEMICAL NAME           : 4-Pyridinecarboxylic acid,
                          ((2-(carboxymethoxy)phenyl)methylene)hydrazide
CAS REGISTRY NUMBER     : 13410-86-1
BEILSTEIN REFERENCE NO. : 0300804
REFERENCE               : 4-22-00-00585 (Beilstein Handbook Reference)
LAST UPDATED            : 199612
DATA ITEMS CITED        : 2
MOLECULAR FORMULA       : C15-H13-N3-O4
MOLECULAR WEIGHT        : 299.31
COMPOUND DESCRIPTOR     : Drug
SYNONYMS/TRADE NAMES :
   * Aconiazide
   * Compound 377
   * Isonicophen
   * Isonicotinic acid, (o-(carboxymethoxy)benzylidene)hydrazide
   * Phenoxalid
 
                       *** HEALTH HAZARD DATA ***
 
                 ** OTHER MULTIPLE DOSE TOXICITY DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 7 gm/kg/14D-I
TOXIC EFFECTS :
   Peripheral Nerve and Sensation - structural change in nerve or sheath
   Liver - fatty liver degeneration
   Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
   JACTDZ Journal of the American College of Toxicology.  (Mary Ann Liebert,
   Inc., 1651 Third Ave., New York, NY 10128)  V.1-12, 1982-1993. Discontinued.
    Volume(issue)/page/year: 12,329,1993
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 36400 mg/kg/26W-I
TOXIC EFFECTS :
   Peripheral Nerve and Sensation - structural change in nerve or sheath
   Blood - changes in erythrocyte (RBC) count
   Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
   JACTDZ Journal of the American College of Toxicology.  (Mary Ann Liebert,
   Inc., 1651 Third Ave., New York, NY 10128)  V.1-12, 1982-1993. Discontinued.
    Volume(issue)/page/year: 14,328,1995
 
                            *** END OF RECORD ***