*** CHEMICAL IDENTIFICATION *** RTECS NUMBER : US5638000 CHEMICAL NAME : 4-Pyridinecarboxylic acid, ((2-(carboxymethoxy)phenyl)methylene)hydrazide CAS REGISTRY NUMBER : 13410-86-1 BEILSTEIN REFERENCE NO. : 0300804 REFERENCE : 4-22-00-00585 (Beilstein Handbook Reference) LAST UPDATED : 199612 DATA ITEMS CITED : 2 MOLECULAR FORMULA : C15-H13-N3-O4 MOLECULAR WEIGHT : 299.31 COMPOUND DESCRIPTOR : Drug SYNONYMS/TRADE NAMES : * Aconiazide * Compound 377 * Isonicophen * Isonicotinic acid, (o-(carboxymethoxy)benzylidene)hydrazide * Phenoxalid *** HEALTH HAZARD DATA *** ** OTHER MULTIPLE DOSE TOXICITY DATA ** TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 7 gm/kg/14D-I TOXIC EFFECTS : Peripheral Nerve and Sensation - structural change in nerve or sheath Liver - fatty liver degeneration Nutritional and Gross Metabolic - weight loss or decreased weight gain REFERENCE : JACTDZ Journal of the American College of Toxicology. (Mary Ann Liebert, Inc., 1651 Third Ave., New York, NY 10128) V.1-12, 1982-1993. Discontinued. Volume(issue)/page/year: 12,329,1993 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 36400 mg/kg/26W-I TOXIC EFFECTS : Peripheral Nerve and Sensation - structural change in nerve or sheath Blood - changes in erythrocyte (RBC) count Nutritional and Gross Metabolic - weight loss or decreased weight gain REFERENCE : JACTDZ Journal of the American College of Toxicology. (Mary Ann Liebert, Inc., 1651 Third Ave., New York, NY 10128) V.1-12, 1982-1993. Discontinued. Volume(issue)/page/year: 14,328,1995 *** END OF RECORD ***