*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : US5675100
CHEMICAL NAME           : 3-Pyridinecarboxylic acid,
                          6-((3,4-dihydro-4,4-dimethyl-2H-1-benzothiopyran-6-yl
                          )ethynyl)-, ethyl ester
CAS REGISTRY NUMBER     : 118292-40-3
LAST UPDATED            : 199801
DATA ITEMS CITED        : 3
MOLECULAR FORMULA       : C21-H21-N-O2-S
MOLECULAR WEIGHT        : 351.49
SYNONYMS/TRADE NAMES :
   * AGN 190168
   * Tazarotene
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD - Lethal dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : >2 gm/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   JAADDB Journal of the American Academy of Dermatology.  (C.V. Mosby Co.,
   11830 Westline Industrial Dr., St. Louis, MO 63141)  1979-
   Volume(issue)/page/year: 37(Suppl),S25,1997
 
                 ** OTHER MULTIPLE DOSE TOXICITY DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 22750 ug/kg/13W-I
TOXIC EFFECTS :
   Musculoskeletal - other changes
REFERENCE :
   JAADDB Journal of the American Academy of Dermatology.  (C.V. Mosby Co.,
   11830 Westline Industrial Dr., St. Louis, MO 63141)  1979-
   Volume(issue)/page/year: 37(Suppl),S25,1997
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Primate - monkey
DOSE/DURATION           : 35 mg/kg/26W-I
TOXIC EFFECTS :
   Musculoskeletal - other changes
REFERENCE :
   JAADDB Journal of the American Academy of Dermatology.  (C.V. Mosby Co.,
   11830 Westline Industrial Dr., St. Louis, MO 63141)  1979-
   Volume(issue)/page/year: 37(Suppl),S25,1997
 
                            *** END OF RECORD ***