*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : US5912000
CHEMICAL NAME           : 3-Pyridinecarboxylic acid, 1,2,5,6-tetrahydro-,
                          methyl ester, hydrochloride
CAS REGISTRY NUMBER     : 6197-39-3
LAST UPDATED            : 199306
DATA ITEMS CITED        : 2
MOLECULAR FORMULA       : C7-H11-N-O2.Cl-H
MOLECULAR WEIGHT        : 177.65
COMPOUND DESCRIPTOR     : Drug
SYNONYMS/TRADE NAMES :
   * Guvacine methyl ester hydrochloride
   * Guvacoline hydrochloride
   * Nicotinic acid, 1,2,5,6-tetrahydro-, methyl ester, hydrochloride
   * Norarecoline hydrochloride
   * 1,2,5,6-Tetrahydro-3-pyridinecarboxylic acid methyl ester hydrochloride
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 750 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   EJMCA5 European Journal of Medicinal Chemistry--Chimie Therapeutique.
   (Editions Scientifiques Elsevier, 29 rue Buffon, F-75005, Paris, France)
   V.9-    1974-  Volume(issue)/page/year: 26,853,1991
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 223 mg/kg
TOXIC EFFECTS :
   Sense Organs and Special Senses (Eye) - ptosis
   Behavioral - somnolence (general depressed activity)
   Skin and Appendages - hair
REFERENCE :
   NEPHBW Neuropharmacology.  (Pergamon Press Ltd., Headington Hill Hall,
   Oxford OX3 OBW, UK) V.9-    1970-  Volume(issue)/page/year: 21 803,1982
 
                            *** END OF RECORD ***