*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : US7968500
CHEMICAL NAME           : 3,5-Pyridinedicarboxylic acid,
                          1,4-dihydro-4-(1,3-benzodioxol-4-yl)-2,6-dimethyl-,
                          ethyl methyl ester
CAS REGISTRY NUMBER     : 90729-41-2
LAST UPDATED            : 199406
DATA ITEMS CITED        : 3
MOLECULAR FORMULA       : C19-H21-N-O6
MOLECULAR WEIGHT        : 359.41
COMPOUND DESCRIPTOR     : Drug
SYNONYMS/TRADE NAMES :
   * IQB-837-V
   * Oxodipine
   * Oxodipino
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 1100 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   DRFUD4 Drugs of the Future.  (J.R. Prous, S.A., Apartado de Correos 540,
   08080 Barcelona, Spain) V.1-    1975/76-  Volume(issue)/page/year:
   12,633,1987
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 150 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   FATOAO Farmakologiya i Toksikologiya (Moscow).  For English translation, see
   PHTXA6 and RPTOAN. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.2-   
   1939-  Volume(issue)/page/year: 54(2),40,1991
 
                 ** OTHER MULTIPLE DOSE TOXICITY DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Mammal - dog
DOSE/DURATION           : 2160 mg/kg/13W-I
TOXIC EFFECTS :
   Vascular - BP lowering not characterized in autonomic section
   Endocrine - other changes
   Endocrine - changes in adrenal weight
REFERENCE :
   TOPADD Toxicologic Pathology.  (c/o Dr. F.A. de la Iglesia, Warner-Lambert
   Co., Pharmaceutical Research Div., POB 1047, Ann Arbor, MI 48106) V.6(3/4)- 
     1978-  Volume(issue)/page/year: 20,549,1992
 
                            *** END OF RECORD ***