*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : US9250000
CHEMICAL NAME           : Pyridine,
                          2-(alpha-(2-(dimethylamino)ethoxy)-alpha-methylbenzyl
                          )-
CAS REGISTRY NUMBER     : 469-21-6
BEILSTEIN REFERENCE NO. : 0230379
REFERENCE               : 5-21-03-00508 (Beilstein Handbook Reference)
LAST UPDATED            : 199612
DATA ITEMS CITED        : 6
MOLECULAR FORMULA       : C17-H22-N2-O
MOLECULAR WEIGHT        : 270.41
WISWESSER LINE NOTATION : T6NJ BX1&R&O2N1&1
SYNONYMS/TRADE NAMES :
   * 2-(alpha-(2-(Dimethylamino)ethoxy)-alpha-methylbenzyl)pyridine
   * 2-Dimethylaminoethoxyphenylmethyl-2-picoline
   * Doxylamine
   * Ethanamine, N,N-dimethyl-2-(1-phenyl-1-(2-pyridinyl)ethoxy)-
   * NCI C60684
   * Phenyl-2-pyridylmethyl-beta-N,N-dimethylaminoethyl ether
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 440 mg/kg
TOXIC EFFECTS :
   Behavioral - convulsions or effect on seizure threshold
REFERENCE :
   DPIRDU Dangerous Properties of Industrial Materials Report.  (Van Nostrand
   Reinhold, 115 Fifth Ave., New York, NY 10003)  V.1-    1981-
   Volume(issue)/page/year: 2(5),17,1982
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 470 mg/kg
TOXIC EFFECTS :
   Behavioral - convulsions or effect on seizure threshold
REFERENCE :
   DPIRDU Dangerous Properties of Industrial Materials Report.  (Van Nostrand
   Reinhold, 115 Fifth Ave., New York, NY 10003)  V.1-    1981-
   Volume(issue)/page/year: 2(5),17,1982
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 460 mg/kg
TOXIC EFFECTS :
   Behavioral - convulsions or effect on seizure threshold
REFERENCE :
   DPIRDU Dangerous Properties of Industrial Materials Report.  (Van Nostrand
   Reinhold, 115 Fifth Ave., New York, NY 10003)  V.1-    1981-
   Volume(issue)/page/year: 2(5),17,1982
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 62 mg/kg
TOXIC EFFECTS :
   Behavioral - convulsions or effect on seizure threshold
REFERENCE :
   DPIRDU Dangerous Properties of Industrial Materials Report.  (Van Nostrand
   Reinhold, 115 Fifth Ave., New York, NY 10003)  V.1-    1981-
   Volume(issue)/page/year: 2(5),17,1982
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : 250 mg/kg
TOXIC EFFECTS :
   Behavioral - convulsions or effect on seizure threshold
   Behavioral - rigidity (including catalepsy)
REFERENCE :
   DPIRDU Dangerous Properties of Industrial Materials Report.  (Van Nostrand
   Reinhold, 115 Fifth Ave., New York, NY 10003)  V.1-    1981-
   Volume(issue)/page/year: 2(5),17,1982
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : 49 mg/kg
TOXIC EFFECTS :
   Behavioral - convulsions or effect on seizure threshold
   Behavioral - rigidity (including catalepsy)
REFERENCE :
   DPIRDU Dangerous Properties of Industrial Materials Report.  (Van Nostrand
   Reinhold, 115 Fifth Ave., New York, NY 10003)  V.1-    1981-
   Volume(issue)/page/year: 2(5),17,1982
 
                            *** END OF RECORD ***