*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : US9625000
CHEMICAL NAME           : Pyridine, 2-(alpha-(2-(dimethylamino)ethyl)benzyl)-
CAS REGISTRY NUMBER     : 86-21-5
BEILSTEIN REFERENCE NO. : 0192445
REFERENCE               : 5-22-10-00487 (Beilstein Handbook Reference)
LAST UPDATED            : 199612
DATA ITEMS CITED        : 4
MOLECULAR FORMULA       : C16-H20-N2
MOLECULAR WEIGHT        : 240.38
WISWESSER LINE NOTATION : T6NJ BYR&2N1&1
COMPOUND DESCRIPTOR     : Drug
                          Human
SYNONYMS/TRADE NAMES :
   * 2-(alpha-(2-Dimethylaminoethyl)benzyl)pyridine
   * 2-(3-Dimethylamino-1-phenylpropyl)pyridine
   * N,N-Dimethyl-3-phenyl-3-(2-pyridyl)propylamine
   * NCI-C60695
   * Pheniramine
   * 1-Phenyl-1-(2-pyridyl)-3-dimethylaminopropane
   * 3-Phenyl-3-(2-pyridyl)-N,N-dimethylpropylanine
   * Prophenpyridamine
   * 2-Pyridinepropanamine, N,N-dimethyl-gamma-phenyl-
   * Trimeton
   * Tripoton
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Human - woman
DOSE/DURATION           : 14 mg/kg
TOXIC EFFECTS :
   Behavioral - hallucinations, distorted perceptions
   Behavioral - muscle contraction or spasticity
REFERENCE :
   MJAUAJ Medical Journal of Australia.  (Australasian Medical Pub. Co. Ltd.,
   71-79 Arundel St., Glebe, N.S.W., Australia)  V.1-    1914-
   Volume(issue)/page/year: 2,110,1976
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 48 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   AEPPAE Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und
   Pharmakologie.  (Berlin, Ger.) V.110-253, 1925-66.  For publisher
   information, see NSAPCC.  Volume(issue)/page/year: 211,328,1950
 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : 30 mg/kg
TOXIC EFFECTS :
   Lungs, Thorax, or Respiration - other changes
   Endocrine - hyperglycemia
   Nutritional and Gross Metabolic - body temperature decrease
REFERENCE :
   AEPPAE Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und
   Pharmakologie.  (Berlin, Ger.) V.110-253, 1925-66.  For publisher
   information, see NSAPCC.  Volume(issue)/page/year: 211,328,1950

         *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***

NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
   NOHS - National Occupational Hazard Survey (1974)
     NOHS Hazard Code - 81485
       No. of Facilities: 805 (estimated)
       No. of Industries: 1
       No. of Occupations: 1
       No. of Employees: 805 (estimated)

 
                            *** END OF RECORD ***