*** CHEMICAL IDENTIFICATION *** RTECS NUMBER : UT0175000 CHEMICAL NAME : Pyridine, 2-(alpha-(2-(dimethylamino)ethyl)benzyl)-, maleate (1:1) CAS REGISTRY NUMBER : 132-20-7 LAST UPDATED : 199701 DATA ITEMS CITED : 11 MOLECULAR FORMULA : C16-H20-N2.C4-H4-O4 MOLECULAR WEIGHT : 356.46 WISWESSER LINE NOTATION : T6NJ BYR&2N1&1 COMPOUND DESCRIPTOR : Drug Mutagen Human SYNONYMS/TRADE NAMES : * Avil-retard * Daneral * 2-(alpha-(2-(Dimethylamino)ethyl)benzyl)pyridine, bimaleate * 2-(alpha-(2-(Dimethylamino)ethyl)benzyl)pyridine, maleate * 1-(N,N-Dimethylamino)-3-(phenyl-3-alpha-pyridyl)propane maleate * HO 11513 * Inhiston * Pheniramine hydrogen maleate * Pheniramine maleate * Phenyl(2-pyridyl)(beta-N,N-dimethylaminomethyl) methane maleate * 1-Phenyl-1-(2-pyridyl)-3-dimethylaminopropane maleate * PM 241 * Prophenpyridamine maleate * 2-Pyridinepropanamine, N,N-dimethyl-gamma-phenyl-, (Z)-2-butenedioate (1:1) * Trimeton maleate * Trimetose *** HEALTH HAZARD DATA *** ** ACUTE TOXICITY DATA ** TYPE OF TEST : LDLo - Lowest published lethal dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Human - child DOSE/DURATION : 30 mg/kg TOXIC EFFECTS : Behavioral - convulsions or effect on seizure threshold Behavioral - antipsychotic Lungs, Thorax, or Respiration - cyanosis REFERENCE : ATXKA8 Archiv fuer Toxikologie. (Berlin, Fed. Rep. Ger.) V.15-31, 1954-74. For publisher information, see ARTODN. Volume(issue)/page/year: 29,317,1972 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 520 mg/kg TOXIC EFFECTS : Behavioral - tremor Behavioral - changes in motor activity (specific assay) Behavioral - aggression REFERENCE : KIZAAL Kurume Igakkai Zasshi. Journal of the Kurume Medical Association. (Kurume Igakkai, 67, Asahi-machi, Kurume 830, Japan) V.9- 1946- Volume(issue)/page/year: 43,168,1980 TYPE OF TEST : LDLo - Lowest published lethal dose ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 200 mg/kg TOXIC EFFECTS : Behavioral - tremor Behavioral - convulsions or effect on seizure threshold Behavioral - excitement REFERENCE : CRSBAW Comptes Rendus des Seances de la Societe de Biologie et de Ses Filiales. (SPPIF, B.P.22, F-41353 Vineuil, France) V.1- 1849- Volume(issue)/page/year: 144,887,1950 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 268 mg/kg TOXIC EFFECTS : Behavioral - tremor Behavioral - changes in motor activity (specific assay) Behavioral - aggression REFERENCE : KIZAAL Kurume Igakkai Zasshi. Journal of the Kurume Medical Association. (Kurume Igakkai, 67, Asahi-machi, Kurume 830, Japan) V.9- 1946- Volume(issue)/page/year: 43,168,1980 TYPE OF TEST : LDLo - Lowest published lethal dose ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Mammal - dog DOSE/DURATION : 111 mg/kg TOXIC EFFECTS : Cardiac - change in rate Vascular - BP lowering not characterized in autonomic section Lungs, Thorax, or Respiration - respiratory stimulation REFERENCE : JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 113,72,1955 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - guinea pig DOSE/DURATION : 270 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : JOALAS Journal of Allergy. (St. Louis, MO) V.1-47, 1929-71. For publisher information, see JACIBY. Volume(issue)/page/year: 27,57,1956 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - guinea pig DOSE/DURATION : 72 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 113,313,1958 ** MUTATION DATA ** TYPE OF TEST : Cytogenetic analysis ROUTE OF EXPOSURE : Oral TEST SYSTEM : Rodent - mouse DOSE/DURATION : 1120 ug/kg REFERENCE : IJEBA6 Indian Journal of Experimental Biology. (Publications & Information Directorate, CSIR, Hillside Rd., New Delhi 110 012, India) V.1- 1963- Volume(issue)/page/year: 19,516,1981 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 83158 No. of Facilities: 1580 (estimated) No. of Industries: 3 No. of Occupations: 9 No. of Employees: 6126 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 83158 No. of Facilities: 12 (estimated) No. of Industries: 1 No. of Occupations: 1 No. of Employees: 494 (estimated) No. of Female Employees: 206 (estimated) *** STATUS IN U.S. *** EPA TSCA Section 8(b) CHEMICAL INVENTORY *** END OF RECORD ***