*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : UT0175000
CHEMICAL NAME           : Pyridine, 2-(alpha-(2-(dimethylamino)ethyl)benzyl)-,
                          maleate (1:1)
CAS REGISTRY NUMBER     : 132-20-7
LAST UPDATED            : 199701
DATA ITEMS CITED        : 11
MOLECULAR FORMULA       : C16-H20-N2.C4-H4-O4
MOLECULAR WEIGHT        : 356.46
WISWESSER LINE NOTATION : T6NJ BYR&2N1&1
COMPOUND DESCRIPTOR     : Drug
                          Mutagen
                          Human
SYNONYMS/TRADE NAMES :
   * Avil-retard
   * Daneral
   * 2-(alpha-(2-(Dimethylamino)ethyl)benzyl)pyridine, bimaleate
   * 2-(alpha-(2-(Dimethylamino)ethyl)benzyl)pyridine, maleate
   * 1-(N,N-Dimethylamino)-3-(phenyl-3-alpha-pyridyl)propane maleate
   * HO 11513
   * Inhiston
   * Pheniramine hydrogen maleate
   * Pheniramine maleate
   * Phenyl(2-pyridyl)(beta-N,N-dimethylaminomethyl) methane maleate
   * 1-Phenyl-1-(2-pyridyl)-3-dimethylaminopropane maleate
   * PM 241
   * Prophenpyridamine maleate
   * 2-Pyridinepropanamine, N,N-dimethyl-gamma-phenyl-, (Z)-2-butenedioate  
   (1:1)
   * Trimeton maleate
   * Trimetose
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Human - child
DOSE/DURATION           : 30 mg/kg
TOXIC EFFECTS :
   Behavioral - convulsions or effect on seizure threshold
   Behavioral - antipsychotic
   Lungs, Thorax, or Respiration - cyanosis
REFERENCE :
   ATXKA8 Archiv fuer Toxikologie.  (Berlin, Fed. Rep. Ger.)  V.15-31, 1954-74.
    For publisher information, see ARTODN.  Volume(issue)/page/year:
   29,317,1972
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 520 mg/kg
TOXIC EFFECTS :
   Behavioral - tremor
   Behavioral - changes in motor activity (specific assay)
   Behavioral - aggression
REFERENCE :
   KIZAAL Kurume Igakkai Zasshi.  Journal of the Kurume Medical Association.
   (Kurume Igakkai, 67, Asahi-machi, Kurume 830, Japan)  V.9-    1946-
   Volume(issue)/page/year: 43,168,1980
 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 200 mg/kg
TOXIC EFFECTS :
   Behavioral - tremor
   Behavioral - convulsions or effect on seizure threshold
   Behavioral - excitement
REFERENCE :
   CRSBAW Comptes Rendus des Seances de la Societe de Biologie et de Ses
   Filiales.  (SPPIF, B.P.22, F-41353 Vineuil, France)  V.1-    1849-
   Volume(issue)/page/year: 144,887,1950
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 268 mg/kg
TOXIC EFFECTS :
   Behavioral - tremor
   Behavioral - changes in motor activity (specific assay)
   Behavioral - aggression
REFERENCE :
   KIZAAL Kurume Igakkai Zasshi.  Journal of the Kurume Medical Association.
   (Kurume Igakkai, 67, Asahi-machi, Kurume 830, Japan)  V.9-    1946-
   Volume(issue)/page/year: 43,168,1980
 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Mammal - dog
DOSE/DURATION           : 111 mg/kg
TOXIC EFFECTS :
   Cardiac - change in rate
   Vascular - BP lowering not characterized in autonomic section
   Lungs, Thorax, or Respiration - respiratory stimulation
REFERENCE :
   JPETAB Journal of Pharmacology and Experimental Therapeutics.  (Williams &
   Wilkins Co., 428 E. Preston St., Baltimore, MD 21202)  V.1-    1909/10-
   Volume(issue)/page/year: 113,72,1955
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - guinea pig
DOSE/DURATION           : 270 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   JOALAS Journal of Allergy.  (St. Louis, MO)  V.1-47, 1929-71.  For publisher
   information, see JACIBY.  Volume(issue)/page/year: 27,57,1956
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - guinea pig
DOSE/DURATION           : 72 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans
   Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium)  V.4-   
   1898-  Volume(issue)/page/year: 113,313,1958
 
                            ** MUTATION DATA **
 
TYPE OF TEST            : Cytogenetic analysis
ROUTE OF EXPOSURE       : Oral
TEST SYSTEM             : Rodent - mouse
DOSE/DURATION           : 1120 ug/kg
REFERENCE :
   IJEBA6 Indian Journal of Experimental Biology.  (Publications & Information
   Directorate, CSIR, Hillside Rd., New Delhi 110 012, India)  V.1-    1963-
   Volume(issue)/page/year: 19,516,1981

         *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***

NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
   NOHS - National Occupational Hazard Survey (1974)
     NOHS Hazard Code - 83158
       No. of Facilities: 1580 (estimated)
       No. of Industries: 3
       No. of Occupations: 9
       No. of Employees: 6126 (estimated)
   
   NOES - National Occupational Exposure Survey (1983)
     NOES Hazard Code - 83158
       No. of Facilities: 12 (estimated)
       No. of Industries: 1
       No. of Occupations: 1
       No. of Employees: 494 (estimated)
       No. of Female Employees: 206 (estimated)

                          *** STATUS IN U.S. ***
 
   EPA TSCA Section 8(b) CHEMICAL INVENTORY

 
                            *** END OF RECORD ***