*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : UT5552000
CHEMICAL NAME           : Pyridine, 2-(2-(methylamino)ethyl)-
CAS REGISTRY NUMBER     : 5638-76-6
BEILSTEIN REFERENCE NO. : 0112294
REFERENCE               : 5-22-09-00368 (Beilstein Handbook Reference)
LAST UPDATED            : 199701
DATA ITEMS CITED        : 6
MOLECULAR FORMULA       : C8-H12-N2
MOLECULAR WEIGHT        : 136.22
WISWESSER LINE NOTATION : T6NJ B2M1
SYNONYMS/TRADE NAMES :
   * Betahistine
   * beta-Histine
   * 2-(2-(Methylamino)ethyl)pyridine
   * N-Methyl-2-pyridineethanamine
   * N-Methyl-N-beta-(2-pyridyl)ethylamine
   * 2-Pyridineethanamine, N-methyl-
   * (2-(2-Pyridyl)ethyl)methylamine
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 6110 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   PBFMAV Problemi na Farmatsiyata.  Problems in Pharmacy.  (Durzhavno
   Izdatel'stvo Meditsina i Fizkultura, Pl. Slaveikov II, Sofia, Bulgaria) V.1-
      1973-  Volume(issue)/page/year: 13,63,1985
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 980 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   PBFMAV Problemi na Farmatsiyata.  Problems in Pharmacy.  (Durzhavno
   Izdatel'stvo Meditsina i Fizkultura, Pl. Slaveikov II, Sofia, Bulgaria) V.1-
      1973-  Volume(issue)/page/year: 13,63,1985
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 2920 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   PBFMAV Problemi na Farmatsiyata.  Problems in Pharmacy.  (Durzhavno
   Izdatel'stvo Meditsina i Fizkultura, Pl. Slaveikov II, Sofia, Bulgaria) V.1-
      1973-  Volume(issue)/page/year: 13,63,1985
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 320 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   PBFMAV Problemi na Farmatsiyata.  Problems in Pharmacy.  (Durzhavno
   Izdatel'stvo Meditsina i Fizkultura, Pl. Slaveikov II, Sofia, Bulgaria) V.1-
      1973-  Volume(issue)/page/year: 13,63,1985
 
                 ** OTHER MULTIPLE DOSE TOXICITY DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 94500 mg/kg/90D-C
TOXIC EFFECTS :
   Behavioral - muscle weakness
   Nutritional and Gross Metabolic - weight loss or decreased weight gain
   Related to Chronic Data - death
REFERENCE :
   OYYAA2 Oyo Yakuri.  Pharmacometrics.  (Oyo Yakuri Kenkyukai, CPO Box 180,
   Sendai 980-91, Japan) V.1-    1967-  Volume(issue)/page/year: 2,344,1968

                          *** STATUS IN U.S. ***
 
   EPA TSCA Section 8(b) CHEMICAL INVENTORY

 
                            *** END OF RECORD ***