*** CHEMICAL IDENTIFICATION *** RTECS NUMBER : UT5552000 CHEMICAL NAME : Pyridine, 2-(2-(methylamino)ethyl)- CAS REGISTRY NUMBER : 5638-76-6 BEILSTEIN REFERENCE NO. : 0112294 REFERENCE : 5-22-09-00368 (Beilstein Handbook Reference) LAST UPDATED : 199701 DATA ITEMS CITED : 6 MOLECULAR FORMULA : C8-H12-N2 MOLECULAR WEIGHT : 136.22 WISWESSER LINE NOTATION : T6NJ B2M1 SYNONYMS/TRADE NAMES : * Betahistine * beta-Histine * 2-(2-(Methylamino)ethyl)pyridine * N-Methyl-2-pyridineethanamine * N-Methyl-N-beta-(2-pyridyl)ethylamine * 2-Pyridineethanamine, N-methyl- * (2-(2-Pyridyl)ethyl)methylamine *** HEALTH HAZARD DATA *** ** ACUTE TOXICITY DATA ** TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 6110 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : PBFMAV Problemi na Farmatsiyata. Problems in Pharmacy. (Durzhavno Izdatel'stvo Meditsina i Fizkultura, Pl. Slaveikov II, Sofia, Bulgaria) V.1- 1973- Volume(issue)/page/year: 13,63,1985 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 980 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : PBFMAV Problemi na Farmatsiyata. Problems in Pharmacy. (Durzhavno Izdatel'stvo Meditsina i Fizkultura, Pl. Slaveikov II, Sofia, Bulgaria) V.1- 1973- Volume(issue)/page/year: 13,63,1985 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 2920 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : PBFMAV Problemi na Farmatsiyata. Problems in Pharmacy. (Durzhavno Izdatel'stvo Meditsina i Fizkultura, Pl. Slaveikov II, Sofia, Bulgaria) V.1- 1973- Volume(issue)/page/year: 13,63,1985 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 320 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : PBFMAV Problemi na Farmatsiyata. Problems in Pharmacy. (Durzhavno Izdatel'stvo Meditsina i Fizkultura, Pl. Slaveikov II, Sofia, Bulgaria) V.1- 1973- Volume(issue)/page/year: 13,63,1985 ** OTHER MULTIPLE DOSE TOXICITY DATA ** TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 94500 mg/kg/90D-C TOXIC EFFECTS : Behavioral - muscle weakness Nutritional and Gross Metabolic - weight loss or decreased weight gain Related to Chronic Data - death REFERENCE : OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 2,344,1968 *** STATUS IN U.S. *** EPA TSCA Section 8(b) CHEMICAL INVENTORY *** END OF RECORD ***