*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : UT5812000
CHEMICAL NAME           : Pyridine,
                          2-(1-(4-methylphenyl)-3-(1-pyrrolidinyl)-1-propenyl)-
                          , (E)-
CAS REGISTRY NUMBER     : 486-12-4
LAST UPDATED            : 199801
DATA ITEMS CITED        : 2
MOLECULAR FORMULA       : C19-H22-N2
MOLECULAR WEIGHT        : 278.43
COMPOUND DESCRIPTOR     : Drug
                          Human
SYNONYMS/TRADE NAMES :
   * (E)-2-(1-(4-Methylphenyl)-3-(1-pyrrolidinyl)-1-propenyl)pyridine
   * Pyridine, 2-(3-(1-pyrrolidinyl)-1-p-tolylpropenyl)-, (E)-
   * trans-1-(2-Pyridyl)-3-pyrrolidino-1-p-tolylprop-1-ene
   * Triprolidin
   * Triprolidine
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Human
DOSE/DURATION           : 143 ug/kg
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
   Behavioral - alteration of operant conditioning
   Behavioral - changes in psychophysiological tests
REFERENCE :
   EJCPAS European Journal of Clinical Pharmacology.  (Springer-Verlag New
   York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094)  V.3- 1970- 
   Volume(issue)/page/year: 47,331,1994
 
                 ** OTHER MULTIPLE DOSE TOXICITY DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 2700 mg/kg/90D-C
TOXIC EFFECTS :
   Gastrointestinal - changes in structure or function of salivary glands
   Liver - fatty liver degeneration
REFERENCE :
   TOXID9 Toxicologist.  (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway,
   Akron, OH 44311) V.1-    1981-  Volume(issue)/page/year: 5,96,1985
 
                            *** END OF RECORD ***