*** CHEMICAL IDENTIFICATION *** RTECS NUMBER : UT7610000 CHEMICAL NAME : 1(4H)-Pyridinepropionic acid, alpha-amino-3-hydroxy-4-oxo- CAS REGISTRY NUMBER : 10182-82-8 LAST UPDATED : 198910 DATA ITEMS CITED : 6 MOLECULAR FORMULA : C8-H10-N2-O4 MOLECULAR WEIGHT : 198.20 WISWESSER LINE NOTATION : T6N DVJ A1YZVQ CQ COMPOUND DESCRIPTOR : Mutagen Reproductive Effector Natural Product SYNONYMS/TRADE NAMES : * 1-L-alpha-Aminopropionil, 3-hydroxi, 4-oxopiridina * beta-(N-(3-Hydroxy-4-pyridone))-alpha-aminopropionic acid * Lecenine * Leucaenine * Leucaenol * Leucenol * Mimosina * Mimosine * 1(4H)-Pyridinealanine, 3-hydroxy-4-oxo- *** HEALTH HAZARD DATA *** ** REPRODUCTIVE DATA ** TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE : 6318 mg/kg SEX/DURATION : female 1-19 day(s) after conception TOXIC EFFECTS : Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants) REFERENCE : TJADAB Teratology, The International Journal of Abnormal Development. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1968- Volume(issue)/page/year: 3,21,1970 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE : 5558 mg/kg SEX/DURATION : female 1-19 day(s) after conception TOXIC EFFECTS : Reproductive - Specific Developmental Abnormalities - musculoskeletal system Reproductive - Maternal Effects - uterus, cervix, vagina REFERENCE : TJADAB Teratology, The International Journal of Abnormal Development. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1968- Volume(issue)/page/year: 3,21,1970 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE : 22750 mg/kg SEX/DURATION : female 42 day(s) pre-mating TOXIC EFFECTS : Reproductive - Maternal Effects - ovaries, fallopian tubes Reproductive - Maternal Effects - uterus, cervix, vagina Reproductive - Fertility - female fertility index (e.g. # females pregnant per # sperm positive females; # females pregnant per # females mated) REFERENCE : BCPCA6 Biochemical Pharmacology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1958- Volume(issue)/page/year: 14,1167,1965 ** MUTATION DATA ** TYPE OF TEST : DNA inhibition TEST SYSTEM : Human Cells - not otherwise specified DOSE/DURATION : 200 umol/L REFERENCE : TOXIA6 Toxicon. (Pergamon Press Ltd., Headington Hill Hall, Oxford OX3 OBW, UK) V.1- 1962- Volume(issue)/page/year: 9,241,1971 TYPE OF TEST : Mutation test systems - not otherwise specified TEST SYSTEM : Human Cells - not otherwise specified DOSE/DURATION : 200 umol/L REFERENCE : TOXIA6 Toxicon. (Pergamon Press Ltd., Headington Hill Hall, Oxford OX3 OBW, UK) V.1- 1962- Volume(issue)/page/year: 9,241,1971 *** REVIEWS *** TOXICOLOGY REVIEW 32XPAD "Teratology," Berry, C.L., and D.E. Poswillo, eds., New York, Springer, 1975 Volume(issue)/page/year: -,49,1975 *** END OF RECORD ***