*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : UU8950000
CHEMICAL NAME           : 2H-Pyrido(3,2-e)-1,4-diazepin-2-one,
                          1,3-dihydro-7-chloro-5-(2-chlorophenyl)-3-hydroxy-
CAS REGISTRY NUMBER     : 42863-81-0
BEILSTEIN REFERENCE NO. : 0690780
LAST UPDATED            : 199612
DATA ITEMS CITED        : 1
MOLECULAR FORMULA       : C14-H9-Cl2-N3-O2
MOLECULAR WEIGHT        : 322.16
WISWESSER LINE NOTATION : T67 BN GMV JN IHJ CG IQ KR BG
COMPOUND DESCRIPTOR     : Drug
                          Human
SYNONYMS/TRADE NAMES :
   *   7-Chloro-5-(2-chlorophenyl)-3-hydroxy-6-aza-1,3-dihydro-2H-1,4-benzodiaz
     epin-2-one
   *   7-Chloro-5-(2-chlorophenyl)-1,3-dihydro-3-hydroxy-2H-pyrido(3,2-e)-1,4-d
     iazepin-2-one
   * D-12524
   * Lopirazepam
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Unreported
SPECIES OBSERVED        : Human - man
DOSE/DURATION           : 107 ug/kg
TOXIC EFFECTS :
   Behavioral - sleep
   Behavioral - ataxia
   Behavioral - antianxiety
REFERENCE :
   DRFUD4 Drugs of the Future.  (J.R. Prous, S.A., Apartado de Correos 540,
   08080 Barcelona, Spain) V.1-    1975/76-  Volume(issue)/page/year: 6,29,1981
 
                            *** END OF RECORD ***