*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : UV0318000
CHEMICAL NAME           : 9H-Pyrido(3,4-b)indole, 1-methyl-, monohydrochloride
CAS REGISTRY NUMBER     : 21655-84-5
LAST UPDATED            : 199007
DATA ITEMS CITED        : 4
MOLECULAR FORMULA       : C12-H10-N2.Cl-H
MOLECULAR WEIGHT        : 218.70
COMPOUND DESCRIPTOR     : Drug
                          Mutagen
SYNONYMS/TRADE NAMES :
   * Harmane hydrochloride
   * Harman hydrochloride
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 66 mg/kg
TOXIC EFFECTS :
   Behavioral - fluid intake
   Behavioral - changes in motor activity (specific assay)
REFERENCE :
   PCJOAU Pharmaceutical Chemistry Journal (English Translation).  Translation
   of KHFZAN. (Plenum Pub. Corp., 233 Spring St., New York, NY 10013)  No.1-
   1967-  Volume(issue)/page/year: 16,894,1982
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intramuscular
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 61 mg/kg
TOXIC EFFECTS :
   Behavioral - convulsions or effect on seizure threshold
   Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
   TIHHAH Tai-wan I Hsueh Hui Tsa Chih.  Journal of the Formosan Medical
   Association.  (Tai-wan I Hsueh Hui, 1, Sect. 1 Jen-ai Road, Taipei, Taiwan)
   V.45-    1946-  Volume(issue)/page/year: 64,44,1965
 
                            ** MUTATION DATA **
 
TYPE OF TEST            : Sister chromatid exchange
TEST SYSTEM             : Human Lymphocyte
DOSE/DURATION           : 58 umol/L
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 90,433,1981

                          *** STATUS IN U.S. ***
 
   EPA GENETOX PROGRAM 1988, Inconclusive: Histidine reversion-Ames test

 
                            *** END OF RECORD ***