*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : UV1120000
CHEMICAL NAME           : 1H-Pyrido(3,4-b)indol-1-one,
                          2,3,4,9-tetrahydro-9-methyl-2-(3-(4-phenyl-1-piperazi
                          nyl) propyl)-, dihydrochloride
CAS REGISTRY NUMBER     : 124824-14-2
LAST UPDATED            : 199712
DATA ITEMS CITED        : 6
MOLECULAR FORMULA       : C25-H30-N4-O.2Cl-H
MOLECULAR WEIGHT        : 475.51
COMPOUND DESCRIPTOR     : Drug
SYNONYMS/TRADE NAMES :
   * B 193
   *   9-Methyl-2-(3-(4-phenyl-1-piperazinylpropyl))-1,2,3,4-tetrahydro-beta-ca
     rbolin-1-one 2HCl
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 650 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   PJPAE3 Polish Journal of Pharmacology.  (Polish Academy of Sciences,
   Institute of Pharmacology, Smetna 12, 31-343 Krakow, Poland)  V.45- 1993- 
   Volume(issue)/page/year: 47,305,1995
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 227 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   PJPAE3 Polish Journal of Pharmacology.  (Polish Academy of Sciences,
   Institute of Pharmacology, Smetna 12, 31-343 Krakow, Poland)  V.45- 1993- 
   Volume(issue)/page/year: 47,305,1995
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 730 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   PJPAE3 Polish Journal of Pharmacology.  (Polish Academy of Sciences,
   Institute of Pharmacology, Smetna 12, 31-343 Krakow, Poland)  V.45- 1993- 
   Volume(issue)/page/year: 47,305,1995
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 90 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   PJPAE3 Polish Journal of Pharmacology.  (Polish Academy of Sciences,
   Institute of Pharmacology, Smetna 12, 31-343 Krakow, Poland)  V.45- 1993- 
   Volume(issue)/page/year: 47,305,1995
 
                 ** OTHER MULTIPLE DOSE TOXICITY DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 90 mg/kg/3W-I
TOXIC EFFECTS :
   Cardiac - changes in heart weight
   Kidney, Ureter, Bladder - changes in bladder weight
REFERENCE :
   PJPAE3 Polish Journal of Pharmacology.  (Polish Academy of Sciences,
   Institute of Pharmacology, Smetna 12, 31-343 Krakow, Poland)  V.45- 1993- 
   Volume(issue)/page/year: 47,305,1995
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 180 mg/kg/3W-I
TOXIC EFFECTS :
   Cardiac - changes in heart weight
   Kidney, Ureter, Bladder - changes in bladder weight
REFERENCE :
   PJPAE3 Polish Journal of Pharmacology.  (Polish Academy of Sciences,
   Institute of Pharmacology, Smetna 12, 31-343 Krakow, Poland)  V.45- 1993- 
   Volume(issue)/page/year: 47,305,1995
 
                            *** END OF RECORD ***