*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : UV8139340
CHEMICAL NAME           : 2,4-Pyrimidinediamine,
                          5-((4-bromo-3,5-dimethoxyphenyl)methyl)-
CAS REGISTRY NUMBER     : 56518-41-3
BEILSTEIN REFERENCE NO. : 0760113
REFERENCE               : 5-25-13-00394 (Beilstein Handbook Reference)
LAST UPDATED            : 199612
DATA ITEMS CITED        : 8
MOLECULAR FORMULA       : C13-H15-Br-N4-O2
MOLECULAR WEIGHT        : 339.23
COMPOUND DESCRIPTOR     : Drug
SYNONYMS/TRADE NAMES :
   * Bromdimoprim
   * 5-((4-Bromo-3,5-dimethoxyphenyl)methyl)-2,4-pyrimidinediamine
   * Ro 10-5970
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 2514 mg/kg
TOXIC EFFECTS :
   Behavioral - excitement
   Lungs, Thorax, or Respiration - other changes
REFERENCE :
   JCHEEU Journal of Chemotherapy.  (Edizioni Riviste Scientifiche, via R.
   Giuliani, 419, 50141 Florence, Italy)  V.1-    1989-
   Volume(issue)/page/year: 5,400,1993
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 3724 mg/kg
TOXIC EFFECTS :
   Behavioral - excitement
   Lungs, Thorax, or Respiration - other changes
REFERENCE :
   JCHEEU Journal of Chemotherapy.  (Edizioni Riviste Scientifiche, via R.
   Giuliani, 419, 50141 Florence, Italy)  V.1-    1989-
   Volume(issue)/page/year: 5,400,1993
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 147 mg/kg
TOXIC EFFECTS :
   Behavioral - convulsions or effect on seizure threshold
REFERENCE :
   JCHEEU Journal of Chemotherapy.  (Edizioni Riviste Scientifiche, via R.
   Giuliani, 419, 50141 Florence, Italy)  V.1-    1989-
   Volume(issue)/page/year: 5,400,1993
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 1054 mg/kg
TOXIC EFFECTS :
   Behavioral - convulsions or effect on seizure threshold
REFERENCE :
   JCHEEU Journal of Chemotherapy.  (Edizioni Riviste Scientifiche, via R.
   Giuliani, 419, 50141 Florence, Italy)  V.1-    1989-
   Volume(issue)/page/year: 5,400,1993
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : >8 gm/kg
TOXIC EFFECTS :
   Behavioral - changes in motor activity (specific assay)
   Lungs, Thorax, or Respiration - respiratory depression
REFERENCE :
   JCHEEU Journal of Chemotherapy.  (Edizioni Riviste Scientifiche, via R.
   Giuliani, 419, 50141 Florence, Italy)  V.1-    1989-
   Volume(issue)/page/year: 5,400,1993
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 104 mg/kg
TOXIC EFFECTS :
   Behavioral - convulsions or effect on seizure threshold
REFERENCE :
   JCHEEU Journal of Chemotherapy.  (Edizioni Riviste Scientifiche, via R.
   Giuliani, 419, 50141 Florence, Italy)  V.1-    1989-
   Volume(issue)/page/year: 5,400,1993
 
                 ** OTHER MULTIPLE DOSE TOXICITY DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 13650 mg/kg/13W-C
TOXIC EFFECTS :
   Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
   JCHEEU Journal of Chemotherapy.  (Edizioni Riviste Scientifiche, via R.
   Giuliani, 419, 50141 Florence, Italy)  V.1-    1989-
   Volume(issue)/page/year: 5,400,1993
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Mammal - dog
DOSE/DURATION           : 1040 mg/kg/13W-C
TOXIC EFFECTS :
   Behavioral - changes in motor activity (specific assay)
   Gastrointestinal - nausea or vomiting
   Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
   JCHEEU Journal of Chemotherapy.  (Edizioni Riviste Scientifiche, via R.
   Giuliani, 419, 50141 Florence, Italy)  V.1-    1989-
   Volume(issue)/page/year: 5,400,1993
 
                            *** END OF RECORD ***