*** CHEMICAL IDENTIFICATION ***
RTECS NUMBER : UV8180000
CHEMICAL NAME : Pyrimidine,
2,4-diamino-5-(3,4-dichlorophenyl)-6-methyl-
CAS REGISTRY NUMBER : 7761-45-7
BEILSTEIN REFERENCE NO. : 0223622
REFERENCE : 5-25-12-00253 (Beilstein Handbook Reference)
LAST UPDATED : 199612
DATA ITEMS CITED : 7
MOLECULAR FORMULA : C11-H10-Cl2-N4
MOLECULAR WEIGHT : 269.15
WISWESSER LINE NOTATION : T6N CNJ BZ DZ ER CG DG& F1
COMPOUND DESCRIPTOR : Mutagen
Reproductive Effector
SYNONYMS/TRADE NAMES :
* BW 50-197
* BW-197U
* 5-(3,4-Dichlorophenyl)-6-methyl-2,4-pyrimidinediamine
* DDMP
* 2,4-Diamino-5-(3,4-dichlorophenyl)-6-methylpyrimidine
* 2,4-Diamino-5-(3',4'-dichlorophenyl)-6-methylpyrimidine
* Methodichlorophen
* Metoprine
* NSC-19494
* 2,4-Pyrimidinediamine, 5-(3,4-dichlorophenyl)-6-methyl-
* U-197
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 7 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
14XBAV "International Congress of Chemotherapy, Proceedings of the 3rd
Congress, 1963," Kuemmerle, H.P., and Prezios, P., Stuttgart, Fed. Rep.
Ger., Georg Thieme Verlag, 1964 Volume(issue)/page/year: -,367,1964
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 50 mg/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold
Tumorigenic - active as anti-cancer agent
REFERENCE :
CTRRDO Cancer Treatment Reports. (Washington, DC) V.60-71, 1976-87. For
publisher information, see JNCIEQ. Volume(issue)/page/year: 60,547,1976
** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 40 mg/kg/21D-I
TOXIC EFFECTS :
Related to Chronic Data - death
REFERENCE :
CTRRDO Cancer Treatment Reports. (Washington, DC) V.60-71, 1976-87. For
publisher information, see JNCIEQ. Volume(issue)/page/year: 60,547,1976
** REPRODUCTIVE DATA **
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE : 2500 ug/kg
SEX/DURATION : female 7 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
e.g., stunted fetus)
Reproductive - Effects on Embryo or Fetus - fetal death
REFERENCE :
PSEBAA Proceedings of the Society for Experimental Biology and Medicine.
(Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1903/04-
Volume(issue)/page/year: 87,571,1954
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE : 5 mg/kg
SEX/DURATION : female 8-9 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
resorbed implants per total number of implants)
REFERENCE :
PSEBAA Proceedings of the Society for Experimental Biology and Medicine.
(Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1903/04-
Volume(issue)/page/year: 87,571,1954
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE : 7500 ug/kg
SEX/DURATION : female 6-8 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - craniofacial
(including nose and tongue)
REFERENCE :
PSEBAA Proceedings of the Society for Experimental Biology and Medicine.
(Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1903/04-
Volume(issue)/page/year: 87,571,1954
** MUTATION DATA **
TYPE OF TEST : Cytogenetic analysis
ROUTE OF EXPOSURE : Unreported
TEST SYSTEM : Human
DOSE/DURATION : 2800 ug/kg
REFERENCE :
RBBIAL Revista Brasileira de Biologia. Brazilian Review of Biology.
(Academia Brasileira de Ciencias, Caixa Postal 229, ZC-00 Rio de Janeiro,
Brazil) V.1- 1941- Volume(issue)/page/year: 25,145,1965
*** END OF RECORD ***