*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : UV9058450
CHEMICAL NAME           : 4,6(1H,5H)-Pyrimidinedione,
                          dihydro-5-ethyl-5-phenyl-, and
                          5-ethyl-5-phenylbarbituric acid
LAST UPDATED            : 198910
DATA ITEMS CITED        : 1
MOLECULAR FORMULA       : C12-H14-N2-O2.C12-H12-N2-O3
MOLECULAR WEIGHT        : 450.54
COMPOUND DESCRIPTOR     : Drug
                          Reproductive Effector
                          Human
SYNONYMS/TRADE NAMES :
   * Phenobarbitone and primidone
   * Primidone and phenobarbitone
 
                       *** HEALTH HAZARD DATA ***
 
                          ** REPRODUCTIVE DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Human - woman
DOSE                    : 3780 mg/kg
SEX/DURATION            : female 1-39 week(s) after conception
TOXIC EFFECTS :
   Reproductive - Specific Developmental Abnormalities - craniofacial
   (including nose and tongue)
   Reproductive - Specific Developmental Abnormalities - musculoskeletal system
   Reproductive - Effects on Newborn - physical
REFERENCE :
   APSVAM Acta Paediatrica Scandinavica.  (Almqvist & Wiksell International,
   POB 4627, S-11691 Stockholm, Sweden)  V.54-80    1965-91    For publisher
   information, see APAEEL  Volume(issue)/page/year: 65,617,1976
 
                            *** END OF RECORD ***