*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : UV9103560
CHEMICAL NAME           : 2,4(1H,3H)-Pyrimidinedione,
                          5-fluoro-1-beta-D-(5'-O-L-valyl)ribofuranosyl-,
                          hydrochloride
CAS REGISTRY NUMBER     : 80667-13-6
LAST UPDATED            : 199706
DATA ITEMS CITED        : 1
MOLECULAR FORMULA       : C14-H20-F-N3-O7.Cl-H
MOLECULAR WEIGHT        : 397.83
COMPOUND DESCRIPTOR     : Drug
SYNONYMS/TRADE NAMES :
   * En-140-521
   * 5-Fluoro-1-beta-D-(5'-O-L-valyl)ribofuranosyl-2,4(1H,3H)-pyrimidinedione  
   hydrochloride
   * 5-Fluoro-1-beta-D-(5'-O-L-valyl)ribofuranosyluracil hydrochloride
   * FO-152
   * L-Valine 5'-ester with 5-fluorouridine hydrochloride
   * 5'-O-L-Valyl-5-fluorouridine hydrochloride
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 330 mg/kg
TOXIC EFFECTS :
   Tumorigenic - active as anti-cancer agent
REFERENCE :
   DRFUD4 Drugs of the Future.  (J.R. Prous, S.A., Apartado de Correos 540,
   08080 Barcelona, Spain) V.1-    1975/76-  Volume(issue)/page/year:
   13,516,1988
 
                            *** END OF RECORD ***