*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : UV9704000
CHEMICAL NAME           : Pyrimidine, 2-(4-piperonyl-1-piperazinyl)-
CAS REGISTRY NUMBER     : 3605-01-4
BEILSTEIN REFERENCE NO. : 0963637
LAST UPDATED            : 199612
DATA ITEMS CITED        : 3
MOLECULAR FORMULA       : C16-H18-N4-O2
MOLECULAR WEIGHT        : 298.38
WISWESSER LINE NOTATION : T56 BO DO CHJ G1- AT6N DNTJ D- BT6N CNJ
COMPOUND DESCRIPTOR     : Drug
SYNONYMS/TRADE NAMES :
   * 2-(4-(1,3-Benzodioxol-5-ylmethyl)-1-piperazinyl)pyrimidine
   * ET 495
   * EU 4200
   * 2-(4-(3,4-Methylenedioxybenzyl)piperazino)pyrimidine
   * 1-(3,4-Methylenedioxybenzyl)-4-(2-pyrimidyl)piperazine
   * 2-(4-Piperonyl-1-piperazinyl)pyrimidine
   * Piribedil
   * 1-(2-Pyrimidyl)-4-piperonylpiperazine
   * 1-(2''-Pyrimidyl)-4-piperonyl piperazine
   * Trivastal
   * Trivastan
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 1460 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   EJPHAZ European Journal of Pharmacology.  (Elsevier Science Pub. B.V., POB
   211, 1000 AE Amsterdam, Netherlands)  V.1-    1967- Volume(issue)/page/year:
   6,75,1969
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 690 mg/kg
TOXIC EFFECTS :
   Vascular - regional or general arteriolar or venous dilation
   Biochemical - Metabolism (Intermediary) - effect on inflammation or
   mediation of inflammation
REFERENCE :
   JMCMAR Journal of Medicinal Chemistry.  (American Chemical Soc.,
   Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC
   20037)  V.6-    1963-  Volume(issue)/page/year: 11,1151,1968
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 88 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   EJPHAZ European Journal of Pharmacology.  (Elsevier Science Pub. B.V., POB
   211, 1000 AE Amsterdam, Netherlands)  V.1-    1967- Volume(issue)/page/year:
   6,75,1969
 
                            *** END OF RECORD ***