*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : UW7681730
CHEMICAL NAME           : 6H-Pyrimido(4,5-b)(1,4)benzothiazine,
                          7,8-dihydro-9-(3,4-dimethoxyphenethylamino)-7,7-
                          dimethyl-4-methoxy-, hydrobromide, hydrate
CAS REGISTRY NUMBER     : 80761-81-5
LAST UPDATED            : 198612
DATA ITEMS CITED        : 2
MOLECULAR FORMULA       : C23-H27-N4-O3-S.Br-H.H2-O
MOLECULAR WEIGHT        : 538.54
WISWESSER LINE NOTATION : T C666 BS DN FN IN NU&&TJ GO1 L1 L1 NM2R CO1 DO1 &EH
                          &QH
COMPOUND DESCRIPTOR     : Drug
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 295 mg/kg
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
   Behavioral - muscle contraction or spasticity
REFERENCE :
   PCJOAU Pharmaceutical Chemistry Journal (English Translation).  Translation
   of KHFZAN. (Plenum Pub. Corp., 233 Spring St., New York, NY 10013)  No.1-
   1967-  Volume(issue)/page/year: 15,785,1981
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 205 mg/kg
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
   Behavioral - muscle contraction or spasticity
REFERENCE :
   PCJOAU Pharmaceutical Chemistry Journal (English Translation).  Translation
   of KHFZAN. (Plenum Pub. Corp., 233 Spring St., New York, NY 10013)  No.1-
   1967-  Volume(issue)/page/year: 15,785,1981
 
                            *** END OF RECORD ***