*** CHEMICAL IDENTIFICATION *** RTECS NUMBER : UX1750000 CHEMICAL NAME : Pyrocatechol, 4,4'-(2,3-dimethyltetramethylene)di- CAS REGISTRY NUMBER : 500-38-9 LAST UPDATED : 199806 DATA ITEMS CITED : 8 MOLECULAR FORMULA : C18-H22-O4 MOLECULAR WEIGHT : 302.40 WISWESSER LINE NOTATION : QR BQ D1Y1&Y1&1R CQ DQ COMPOUND DESCRIPTOR : Mutagen SYNONYMS/TRADE NAMES : * 2,3-Bis(3,4-dihydroxyphenylmethyl)butane * Butane, 1,4-bis(3,4-dihydroxyphenyl)-2,3-dimethyl- * Dihydronorguaiaretic acid * beta,gamma-Dimethyl-alpha,delta-bis(3,4-dihydroxyphenyl)butane * 4,4'-(2,3-Dimethyltetramethylene)dipyrocatechol * Dinorguaiaretic acid, dihydro- * NDGA * Nordihydroguaiaretic acid * Nordihydroguairaretic acid * Norguaiaretic acid, dihydro- *** HEALTH HAZARD DATA *** ** ACUTE TOXICITY DATA ** TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 2 gm/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : JAOCA7 Journal of the American Oil Chemists' Society. (Champaign, IL) V.24-56, 1947-79. Volume(issue)/page/year: 54,239,1977 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 2 gm/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : JAOCA7 Journal of the American Oil Chemists' Society. (Champaign, IL) V.24-56, 1947-79. Volume(issue)/page/year: 54,239,1977 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 550 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : AFREAW Advances in Food Research. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1-32, 1948-88. Volume(issue)/page/year: 3,197,1951 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - guinea pig DOSE/DURATION : 830 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : AFREAW Advances in Food Research. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1-32, 1948-88. Volume(issue)/page/year: 3,197,1951 ** MUTATION DATA ** TYPE OF TEST : Mutation test systems - not otherwise specified TEST SYSTEM : Human Lymphocyte DOSE/DURATION : 13500 nmol/L REFERENCE : MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 412,139,1998 TYPE OF TEST : Sister chromatid exchange TEST SYSTEM : Human Lymphocyte DOSE/DURATION : 3600 nmol/L REFERENCE : MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 412,139,1998 TYPE OF TEST : Mutation test systems - not otherwise specified ROUTE OF EXPOSURE : Intraperitoneal TEST SYSTEM : Rodent - mouse DOSE/DURATION : 70700 ug/kg REFERENCE : MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 412,139,1998 TYPE OF TEST : Sister chromatid exchange ROUTE OF EXPOSURE : Intraperitoneal TEST SYSTEM : Rodent - mouse DOSE/DURATION : 35300 ug/kg REFERENCE : MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 412,139,1998 *** END OF RECORD ***