*** CHEMICAL IDENTIFICATION ***
RTECS NUMBER : UX6825000
CHEMICAL NAME : Pyrophosphoric acid, tetraethyl ester
CAS REGISTRY NUMBER : 107-49-3
BEILSTEIN REFERENCE NO. : 1714017
REFERENCE : 4-01-00-01342 (Beilstein Handbook Reference)
LAST UPDATED : 199806
DATA ITEMS CITED : 55
MOLECULAR FORMULA : C8-H20-O7-P2
MOLECULAR WEIGHT : 290.22
WISWESSER LINE NOTATION : 2OPO&O2&OPO&O2&O2
COMPOUND DESCRIPTOR : Agricultural Chemical
Drug
Human
SYNONYMS/TRADE NAMES :
* Bis-O,O-diethylphosphoric anhydride
* Bladan
* Diphosphoric acid tetraethyl ester
* EA 1285
* ENT 18,771
* Ethyl pyrophosphate, tetra-
* Fosvex
* Grisol
* HEPT
* Hexamite
* Killex
* Kilmite 40
* Lethalaire G-52
* Lirohex
* Mortopal
* Nifos
* Nifos T
* Pyrophosphate de tetraethyle
* RCRA waste number P111
* TEPP
* O,O,O,O-Tetraethyl-difosfaat
* Tetraethyldifosfat
* Tetraethyl diphosphate
* O,O,O,O-Tetraetil-pirofosfato
* Tetraethyl pyrofosfaat
* Tetraethylpyrofosfat
* Tetraethyl pyrophosphate
* Tetraaethylpyrophosphorsaeureester
* Tetrastigmine
* Tetron
* Tetron-100
* Vapotone
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Human
DOSE/DURATION : 1429 ug/kg
TOXIC EFFECTS :
Peripheral Nerve and Sensation - paresthesis
Behavioral - excitement
Gastrointestinal - nausea or vomiting
REFERENCE :
CMEP** "Clinical Memoranda on Economic Poisons," U.S. Dept. HEW, Public
Health Service, Communicable Disease Center, Atlanta, GA, 1956
Volume(issue)/page/year: -,1,1956
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Human
DOSE/DURATION : 309 ug/kg
TOXIC EFFECTS :
Behavioral - wakefulness
Behavioral - muscle contraction or spasticity
Gastrointestinal - other changes
REFERENCE :
CMEP** "Clinical Memoranda on Economic Poisons," U.S. Dept. HEW, Public
Health Service, Communicable Disease Center, Atlanta, GA, 1956
Volume(issue)/page/year: -,1,1956
TYPE OF TEST : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE : Intramuscular
SPECIES OBSERVED : Human
DOSE/DURATION : 286 ug/kg
TOXIC EFFECTS :
Peripheral Nerve and Sensation - paresthesis
Behavioral - excitement
Gastrointestinal - nausea or vomiting
REFERENCE :
CMEP** "Clinical Memoranda on Economic Poisons," U.S. Dept. HEW, Public
Health Service, Communicable Disease Center, Atlanta, GA, 1956
Volume(issue)/page/year: -,1,1956
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Parenteral
SPECIES OBSERVED : Human
DOSE/DURATION : 71 ug/kg
TOXIC EFFECTS :
Behavioral - wakefulness
Behavioral - muscle contraction or spasticity
Gastrointestinal - other changes
REFERENCE :
CMEP** "Clinical Memoranda on Economic Poisons," U.S. Dept. HEW, Public
Health Service, Communicable Disease Center, Atlanta, GA, 1956
Volume(issue)/page/year: -,1,1956
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 500 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
PHJOAV Pharmaceutical Journal. (Pharmaceutical Soc. of Great Britain, 1
Lambeth High St., London, SE1 7JN, UK) V.131- 1933-
Volume(issue)/page/year: 185,361,1960
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Administration onto the skin
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 2400 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year:
14,515,1969
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 650 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
FEPRA7 Federation Proceedings, Federation of American Societies for
Experimental Biology. (Bethesda, MD) V.1-46, 1942-87.
Volume(issue)/page/year: 6,353,1947
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 279 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.1- 1981- Volume(issue)/page/year:
4,S195,1984
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 300 ug/kg
TOXIC EFFECTS :
Biochemical - Enzyme inhibition, induction, or change in blood or tissue
levels - other esterases
REFERENCE :
CJBPAZ Canadian Journal of Biochemistry and Physiology. (Ottawa, Ont.,
Canada) V.32-41, 1954-63. For publisher information, see CJBIAE.
Volume(issue)/page/year: 34,197,1956
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intramuscular
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 1800 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JCINAO Journal of Clinical Investigation. (Rockefeller Univ. Press, 1230
York Ave., New York, NY 10021) V.1- 1924- Volume(issue)/page/year:
37,350,1958
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Unreported
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 1120 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
30ZDA9 "Chemistry of Pesticides," Melnikov, N.N., New York, Springer-Verlag
New York, Inc., 1971 Volume(issue)/page/year: -,379,1971
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 3 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
ABCHA6 Agricultural and Biological Chemistry. (Maruzen Co. Ltd., POB 5050,
Tokyo International, Tokyo 100-31, Japan) V.25- 1961-
Volume(issue)/page/year: 27,684,1963
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Administration onto the skin
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 8 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
ABCHA6 Agricultural and Biological Chemistry. (Maruzen Co. Ltd., POB 5050,
Tokyo International, Tokyo 100-31, Japan) V.25- 1961-
Volume(issue)/page/year: 27,684,1963
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 830 ug/kg
TOXIC EFFECTS :
Biochemical - Enzyme inhibition, induction, or change in blood or tissue
levels - true cholinesterase
REFERENCE :
AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans
Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4-
1898- Volume(issue)/page/year: 121,104,1959
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 500 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag,
Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951-
Volume(issue)/page/year: 29,875,1979
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 200 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
BJPCAL British Journal of Pharmacology and Chemotherapy. (London, UK)
V.1-33, 1946-68. For publisher information, see BJPCBM.
Volume(issue)/page/year: 9,299,1954
TYPE OF TEST : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE : Administration onto the skin
SPECIES OBSERVED : Rodent - rabbit
DOSE/DURATION : 17 uL/kg
TOXIC EFFECTS :
Behavioral - excitement
Gastrointestinal - changes in structure or function of salivary glands
Lungs, Thorax, or Respiration - respiratory stimulation
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: OTS0534856
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Rodent - rabbit
DOSE/DURATION : 2 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
IAEC** Interagency Collaborative Group on Environmental Carcinogenesis,
National Cancer Institute, Memorandum, June 17, 1974
Volume(issue)/page/year: 17JUN1974
TYPE OF TEST : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Rodent - rabbit
DOSE/DURATION : 300 ug/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold
Cardiac - pulse rate
Lungs, Thorax, or Respiration - other changes
REFERENCE :
BJPCAL British Journal of Pharmacology and Chemotherapy. (London, UK)
V.1-33, 1946-68. For publisher information, see BJPCBM.
Volume(issue)/page/year: 8,466,1953
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Unreported
SPECIES OBSERVED : Rodent - rabbit
DOSE/DURATION : 1 mg/kg
TOXIC EFFECTS :
Biochemical - Enzyme inhibition, induction, or change in blood or tissue
levels - true cholinesterase
REFERENCE :
AJOPAA American Journal of Ophthalmology. (Ophthalmic Pub. Co., 435 N.
Michigan Ave., Suite 1415, Chicago, IL 60611) Series 3: V.1- 1918-
Volume(issue)/page/year: 53,512,1962
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - guinea pig
DOSE/DURATION : 2300 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams &
Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10-
Volume(issue)/page/year: 105,156,1952
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Rodent - guinea pig
DOSE/DURATION : 700 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
BJPCAL British Journal of Pharmacology and Chemotherapy. (London, UK)
V.1-33, 1946-68. For publisher information, see BJPCBM.
Volume(issue)/page/year: 14,5,1959
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Bird - pigeon
DOSE/DURATION : 180 ug/kg
TOXIC EFFECTS :
Peripheral Nerve and Sensation - flaccid paralysis without anesthesia
(usually neuromuscular blockage)
Sense Organs and Special Senses (Eye) - effect, not otherwise specified
REFERENCE :
AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans
Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4-
1898- Volume(issue)/page/year: 102,371,1955
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Bird - duck
DOSE/DURATION : 3560 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year:
47,451,1979
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Administration onto the skin
SPECIES OBSERVED : Bird - duck
DOSE/DURATION : 64 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year:
47,451,1979
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Parenteral
SPECIES OBSERVED : Amphibian - frog
DOSE/DURATION : 34 mg/kg
TOXIC EFFECTS :
Peripheral Nerve and Sensation - flaccid paralysis without anesthesia
(usually neuromuscular blockage)
Behavioral - altered sleep time (including change in righting reflex)
Lungs, Thorax, or Respiration - other changes
REFERENCE :
AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans
Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4-
1898- Volume(issue)/page/year: 124,212,1960
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Bird - wild bird species
DOSE/DURATION : 1300 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year:
21,315,1972
*** REVIEWS ***
ACGIH TLV-TWA 0.047 mg/m3 (0.004 ppm) (skin)
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
TLV/BEI,1997
TOXICOLOGY REVIEW
CRTXB2 CRC Critical Reviews in Toxicology. (CRC Press, Inc., 2000 Corporate
Blvd., NW, Boca Raton, FL 33431) V.1- 1971- Volume(issue)/page/year:
3,289,1975
TOXICOLOGY REVIEW
AQMOAC Air Quality Monographs. (Washington, DC) No.69-1 - No.75-25,
1969-75(?). Discontinued. Volume(issue)/page/year: #73-19,1973
TOXICOLOGY REVIEW
RREVAH Residue Reviews. (Springer-Verlag New York, Inc., Service Center, 44
Hartz Way, Secaucus, NJ 07094) V.1- 1962- Volume(issue)/page/year:
46,1,1973
TOXICOLOGY REVIEW
IRXPAT International Review of Experimental Pathology. (Academic Press,
Inc., 1 E. First St., Duluth, MN 55802) V.1- 1962-
Volume(issue)/page/year: 3,219,1964
*** U.S. STANDARDS AND REGULATIONS ***
MSHA STANDARD-air:TWA 0.004 ppm (0.05 mg/m3)
DTLWS* "Documentation of the Threshold Limit Values for Substances in
Workroom Air," Supplements. For publisher information, see 85INA8.
Volume(issue)/page/year: 3,28,1973
OSHA PEL (Gen Indu):8H TWA 0.05 mg/m3 (skin)
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
29,1910.1000,1994
OSHA PEL (Construc):8H TWA 0.05 mg/m3 (skin)
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
29,1926.55,1994
OSHA PEL (Shipyard):8H TWA 0.05 mg/m3 (skin)
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
29,1915.1000,1993
OSHA PEL (Fed Cont):8H TWA 0.05 mg/m3 (skin)
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
41,50-204.50,1994
*** OCCUPATIONAL EXPOSURE LIMITS ***
OEL-ARAB Republic of Egypt:TWA 0.004 ppm (0.05 mg/m3);Skin JAN 1993
OEL-AUSTRALIA:TWA 0.004 ppm (0.05 mg/m3);Skin JAN 1993
OEL-BELGIUM:TWA 0.004 ppm (0.047 mg/m3);Skin JAN 1993
OEL-DENMARK:TWA 0.004 ppm (0.05 mg/m3);Skin JAN 1993
OEL-FRANCE:TWA 0.004 ppm (0.05 mg/m3);Skin JAN 1993
OEL-GERMANY:TWA 0.005 ppm (0.05 mg/m3);Skin JAN 1993
OEL-THE NETHERLANDS:TWA 0.004 ppm (0.05 mg/m3);Skin JAN 1993
OEL-THE PHILIPPINES:TWA 0.05 mg/m3;Skin JAN 1993
OEL-SWITZERLAND:TWA 0.005 ppm (0.05 mg/m3);Skin JAN 1993
OEL-TURKEY:TWA 0.05 mg/m3;Skin JAN 1993
OEL-UNITED KINGDOM:TWA 0.004 ppm (0.05 mg/m3);STEL 0.01 ppm (0.2 mg/m3);Skin
JAN 1993
OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV
OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH RECOMMENDED EXPOSURE LEVEL (REL) :
NIOSH REL TO TEPP-air:10H TWA 0.05 mg/m3 (Sk)
REFERENCE :
NIOSH* National Institute for Occupational Safety and Health, U.S. Dept. of
Health, Education, and Welfare, Reports and Memoranda.
Volume(issue)/page/year: DHHS #92-100,1992
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOHS - National Occupational Hazard Survey (1974)
NOHS Hazard Code - 71680
No. of Facilities: 9 (estimated)
No. of Industries: 1
No. of Occupations: 14
No. of Employees: 1434 (estimated)
*** STATUS IN U.S. ***
On EPA IRIS database
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1998
NIOSH Analytical Method, 1994: Tetraethyl pyrophosphate, 2504
*** END OF RECORD ***