*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : UY0360000
CHEMICAL NAME           : 2-Pyrrolidinecarboxanilide,
                          1-butyl-2',4',6'-trimethyl-, monohydrochloride
CAS REGISTRY NUMBER     : 19089-24-8
LAST UPDATED            : 199603
DATA ITEMS CITED        : 8
MOLECULAR FORMULA       : C18-H28-N2-O.Cl-H
MOLECULAR WEIGHT        : 324.94
WISWESSER LINE NOTATION : T5NTJ A4 BVMR B1 D1 F1 &GH
COMPOUND DESCRIPTOR     : Drug
SYNONYMS/TRADE NAMES :
   * Bumecaine hydrochloride
   * N-Butyl-alpha-pyrrolidine-carboxy-mesidide hydrochloride
   * 1-Butyl-2',4',6'-trimethyl-2-pyrrolidinecarboxanilide hydrochloride
   * Pyromecaine hydrochloride
   * 2-Pyrrolidinecarboxamide, 1-butyl-N-(2,4,6-trimethylphenyl)-,  
   monohydrochloride
   * Pyrromecaine hydrochloride
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 13958 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   STOAAT Stomatologiia (Moscow).  (V/O Mezhdunarodnaya Kniga, 113095 Moscow,
   USSR)  V.1-    1923-  Volume(issue)/page/year: 59(5),27,1980
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 13512 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   STOAAT Stomatologiia (Moscow).  (V/O Mezhdunarodnaya Kniga, 113095 Moscow,
   USSR)  V.1-    1923-  Volume(issue)/page/year: 59(5),27,1980
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 290 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   RPTOAN Russian Pharmacology and Toxicology (English Translation).
   Translation of FATOAO.  (Euromed Pub., 33, Woodlands Rd., Surbiton, Surrey,
   UK)  V.30-    1967-  Volume(issue)/page/year: 46,202,1983
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 128 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   RPTOAN Russian Pharmacology and Toxicology (English Translation).
   Translation of FATOAO.  (Euromed Pub., 33, Woodlands Rd., Surbiton, Surrey,
   UK)  V.30-    1967-  Volume(issue)/page/year: 46,202,1983
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 285 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   RPTOAN Russian Pharmacology and Toxicology (English Translation).
   Translation of FATOAO.  (Euromed Pub., 33, Woodlands Rd., Surbiton, Surrey,
   UK)  V.30-    1967-  Volume(issue)/page/year: 46,202,1983
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 42 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   RPTOAN Russian Pharmacology and Toxicology (English Translation).
   Translation of FATOAO.  (Euromed Pub., 33, Woodlands Rd., Surbiton, Surrey,
   UK)  V.30-    1967-  Volume(issue)/page/year: 35,114,1972
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - guinea pig
DOSE/DURATION           : 6283 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   STOAAT Stomatologiia (Moscow).  (V/O Mezhdunarodnaya Kniga, 113095 Moscow,
   USSR)  V.1-    1923-  Volume(issue)/page/year: 59(5),27,1980
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - guinea pig
DOSE/DURATION           : 4712 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   STOAAT Stomatologiia (Moscow).  (V/O Mezhdunarodnaya Kniga, 113095 Moscow,
   USSR)  V.1-    1923-  Volume(issue)/page/year: 59(5),27,1980
 
                            *** END OF RECORD ***