*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : UY1430000
CHEMICAL NAME           : Pyrrolidine,
                          1-(3-methyl-4-morpholino-2,2-diphenylbutyryl)-, (+)-,
                          tartrate (1:1)
CAS REGISTRY NUMBER     : 2922-44-3
OTHER CAS REGISTRY NOS. : 3528-84-5
LAST UPDATED            : 199103
DATA ITEMS CITED        : 4
MOLECULAR FORMULA       : C25-H32-N2-O2.C4-H6-O6
MOLECULAR WEIGHT        : 542.69
WISWESSER LINE NOTATION : T6N DOTJ A1Y1&XR&R&V- AT5NTJ &QVYQYQVQ
COMPOUND DESCRIPTOR     : Drug
                          Reproductive Effector
SYNONYMS/TRADE NAMES :
   * Dextromoramide bitartrate
   * Dextromoramide tartrate
   * Dimorlin tartrate
   * Jetrium tartrate
   * d-3-Methyl-2,2-diphenyl-4-morpholinobutyrylpyrrolidine tartrate
   * (+)-1-(3-Methyl-4-morpholino-2,2-diphenylbutyryl)pyrrolidine tartrate
   * D-Moramide tartrate
   * Palfium
   * Palphium tartrate
   * Pyrrolamidol tartrate
   * R-875 tartrate
   * SKF 5137 tartrate
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 71800 ug/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   ARZNAD Arzneimittel-Forschung. Drug Research.  (Editio Cantor Verlag,
   Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.)  V.1-    1951-
   Volume(issue)/page/year: 21,862,1971
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 54 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   ARZNAD Arzneimittel-Forschung. Drug Research.  (Editio Cantor Verlag,
   Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.)  V.1-    1951-
   Volume(issue)/page/year: 21,862,1971
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 150 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans
   Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium)  V.4-   
   1898-  Volume(issue)/page/year: 135,462,1962
 
                          ** REPRODUCTIVE DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE                    : 28 mg/kg
SEX/DURATION            : female 9 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Specific Developmental Abnormalities - Central Nervous System
   Reproductive - Specific Developmental Abnormalities - craniofacial
   (including nose and tongue)
REFERENCE :
   TJADAB Teratology, The International Journal of Abnormal Development. (Alan
   R. Liss, Inc., 41 E. 11th St., New York, NY 10003)  V.1-    1968-
   Volume(issue)/page/year: 42,45,1990
 
                            *** END OF RECORD ***