*** CHEMICAL IDENTIFICATION *** RTECS NUMBER : CB4584250 CHEMICAL NAME : 4H-Anthra(1,2-b)pyran-4,7,12-trione, 10-(4-O-acetyl-2,3,6-trideoxy-3-(dimethylamino)-3-C- methyl-alpha-L-lyxo-hexopyranosyl)-11-hydroxy-5-methy l-2-(2-methyl-3-(1-pr openyl)oxiranyl)- 8-(2,3,6-trideoxy-3-(dimethylamino)-beta-D-arabino-he xopyranosyl)- CAS REGISTRY NUMBER : 11016-27-6 BEILSTEIN REFERENCE NO. : 1615057 LAST UPDATED : 199612 DATA ITEMS CITED : 6 MOLECULAR FORMULA : C43-H52-N2-O11 MOLECULAR WEIGHT : 772.97 WISWESSER LINE NOTATION : T D6 B666 CV JV OV ROJ EQ M1 F- FT6OTJ B1 COV1 D1 DN1&1& H- FT6OTJ B1 CQ DN1&1& Q- BT3OTJ B1 COMPOUND DESCRIPTOR : Drug Mutagen Natural Product SYNONYMS/TRADE NAMES : * Pluramycin A *** HEALTH HAZARD DATA *** ** ACUTE TOXICITY DATA ** TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 6250 ug/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : JAJAAA Journal of Antibiotics, Series A. (Tokyo, Japan) V.6-20, 1953-67. For publisher information, see JANTAJ. Volume(issue)/page/year: 10,143,1957 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 25 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : JAJAAA Journal of Antibiotics, Series A. (Tokyo, Japan) V.6-20, 1953-67. For publisher information, see JANTAJ. Volume(issue)/page/year: 10,143,1957 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 1250 ug/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : JAJAAA Journal of Antibiotics, Series A. (Tokyo, Japan) V.6-20, 1953-67. For publisher information, see JANTAJ. Volume(issue)/page/year: 10,143,1957 ** OTHER MULTIPLE DOSE TOXICITY DATA ** TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 75 mg/kg/30D-I TOXIC EFFECTS : Related to Chronic Data - death REFERENCE : JAJAAA Journal of Antibiotics, Series A. (Tokyo, Japan) V.6-20, 1953-67. For publisher information, see JANTAJ. Volume(issue)/page/year: 10,143,1957 ** MUTATION DATA ** TYPE OF TEST : Phage inhibition capacity TEST SYSTEM : Bacteria - Escherichia coli DOSE/DURATION : 2500 ug/L REFERENCE : APMBAY Applied Microbiology. (Washington, DC) V.1-30, 1953-75. For publisher information, see AEMIDF. Volume(issue)/page/year: 12,234,1964 TYPE OF TEST : DNA inhibition TEST SYSTEM : Fish - salmon Sperm DOSE/DURATION : 1 mg/L REFERENCE : JOBIAO Journal of Biochemistry (Tokyo). (Japanese Biochemical Soc., c/o Japan Academic Soc. Center, 2-4-16 Yayoi, Bunkyo-ku, Tokyo 113, Japan) V.1- 1922- Volume(issue)/page/year: 67,655,1970 *** END OF RECORD ***