*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : CB4584250
CHEMICAL NAME           : 4H-Anthra(1,2-b)pyran-4,7,12-trione,
                          10-(4-O-acetyl-2,3,6-trideoxy-3-(dimethylamino)-3-C-
                          methyl-alpha-L-lyxo-hexopyranosyl)-11-hydroxy-5-methy
                          l-2-(2-methyl-3-(1-pr openyl)oxiranyl)-
                          8-(2,3,6-trideoxy-3-(dimethylamino)-beta-D-arabino-he
                          xopyranosyl)-
CAS REGISTRY NUMBER     : 11016-27-6
BEILSTEIN REFERENCE NO. : 1615057
LAST UPDATED            : 199612
DATA ITEMS CITED        : 6
MOLECULAR FORMULA       : C43-H52-N2-O11
MOLECULAR WEIGHT        : 772.97
WISWESSER LINE NOTATION : T D6 B666 CV JV OV ROJ EQ M1 F- FT6OTJ B1 COV1 D1
                          DN1&1& H- FT6OTJ B1 CQ DN1&1& Q- BT3OTJ B1
COMPOUND DESCRIPTOR     : Drug
                          Mutagen
                          Natural Product
SYNONYMS/TRADE NAMES :
   * Pluramycin A
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 6250 ug/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   JAJAAA Journal of Antibiotics, Series A.  (Tokyo, Japan)  V.6-20, 1953-67.
   For publisher information, see JANTAJ.  Volume(issue)/page/year: 10,143,1957
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 25 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   JAJAAA Journal of Antibiotics, Series A.  (Tokyo, Japan)  V.6-20, 1953-67.
   For publisher information, see JANTAJ.  Volume(issue)/page/year: 10,143,1957
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 1250 ug/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   JAJAAA Journal of Antibiotics, Series A.  (Tokyo, Japan)  V.6-20, 1953-67.
   For publisher information, see JANTAJ.  Volume(issue)/page/year: 10,143,1957
 
                 ** OTHER MULTIPLE DOSE TOXICITY DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 75 mg/kg/30D-I
TOXIC EFFECTS :
   Related to Chronic Data - death
REFERENCE :
   JAJAAA Journal of Antibiotics, Series A.  (Tokyo, Japan)  V.6-20, 1953-67.
   For publisher information, see JANTAJ.  Volume(issue)/page/year: 10,143,1957
 
                            ** MUTATION DATA **
 
TYPE OF TEST            : Phage inhibition capacity
TEST SYSTEM             : Bacteria - Escherichia coli
DOSE/DURATION           : 2500 ug/L
REFERENCE :
   APMBAY Applied Microbiology.  (Washington, DC)  V.1-30, 1953-75.  For
   publisher information, see AEMIDF.  Volume(issue)/page/year: 12,234,1964
 
TYPE OF TEST            : DNA inhibition
TEST SYSTEM             : Fish - salmon Sperm
DOSE/DURATION           : 1 mg/L
REFERENCE :
   JOBIAO Journal of Biochemistry (Tokyo).  (Japanese Biochemical Soc., c/o
   Japan Academic Soc. Center, 2-4-16 Yayoi, Bunkyo-ku, Tokyo 113, Japan) V.1- 
     1922-  Volume(issue)/page/year: 67,655,1970
 
                            *** END OF RECORD ***