*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : UY2670000
CHEMICAL NAME           : Pyrrolidinium,
                          1-((7-(((2-amino-4-thiazolyl)(methoxyimino)acetyl)ami
                          no)-2-carboxy-8-oxo-5-
                          thia-1-azabicyclo(4.2.0)oct-2-en-3-yl)methyl)-1-methy
                          l-, hydroxide, inner salt, dihydrochloride, hydrate,
                          (6R-(6-alpha,7-beta(Z)))-
LAST UPDATED            : 199612
DATA ITEMS CITED        : 3
MOLECULAR FORMULA       : C19-H24-N6-O5-S2.2Cl-H.H2-O
MOLECULAR WEIGHT        : 570.54
COMPOUND DESCRIPTOR     : Drug
SYNONYMS/TRADE NAMES :
   * BMY 28142 dihydrochloride hydrate
   * Cefepime dihydrochloride hydrate
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD - Lethal dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : >2 gm/kg
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
   Skin and Appendages - dermatitis, other (after systemic exposure)
REFERENCE :
   JJANAX Japanese Journal of Antibiotics.  (Japan Antibiotics Research Assoc.,
   2-20-8 Kamiosaki, Shinagawa-ku, Tokyo 141, Japan)  V.21-    1968-
   Volume(issue)/page/year: 45,612,1992
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 1067 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   IYKEDH Iyakuhin Kenkyu.  Study of Medical Supplies.  (Nippon Koteisho
   Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan)  V.1- 1970- 
   Volume(issue)/page/year: 26,740,1995
 
TYPE OF TEST            : LD - Lethal dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Mammal - dog
DOSE/DURATION           : >2 gm/kg
TOXIC EFFECTS :
   Behavioral - altered sleep time (including change in righting reflex)
   Gastrointestinal - changes in structure or function of salivary glands
   Kidney, Ureter, Bladder - other changes
REFERENCE :
   JJANAX Japanese Journal of Antibiotics.  (Japan Antibiotics Research Assoc.,
   2-20-8 Kamiosaki, Shinagawa-ku, Tokyo 141, Japan)  V.21-    1968-
   Volume(issue)/page/year: 45,612,1992
 
                            *** END OF RECORD ***