*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : UY5749237
CHEMICAL NAME           : 2-Pyrrolidinone,
                          4-(3-(cyclopentyloxy)-4-methoxyphenyl)-
CAS REGISTRY NUMBER     : 61413-54-5
BEILSTEIN REFERENCE NO. : 1588548
LAST UPDATED            : 199806
DATA ITEMS CITED        : 5
MOLECULAR FORMULA       : C16-H21-N-O3
MOLECULAR WEIGHT        : 275.38
COMPOUND DESCRIPTOR     : Drug
SYNONYMS/TRADE NAMES :
   * 4-(3-(Cyclopentyloxy)-4-methoxyphenyl)-2-pyrrolidinone
   * Rolipram
   * ZK 62711
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD - Lethal dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : >300 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   BPBLEO Biological and Pharmaceutical Bulletin.  (Pharmaceutical Society of
   Japan, 2-12-15-201 Shibuya Shibuya-ku, Tokyo 150, Japan)  V.16-    1993-
   Volume(issue)/page/year: 17,498,1994
 
                 ** OTHER MULTIPLE DOSE TOXICITY DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 1400 mg/kg/14D-I
TOXIC EFFECTS :
   Cardiac - other changes
   Gastrointestinal - changes in structure or function of salivary glands
   Liver - hepatitis (hepatocellular necrosis), zonal
REFERENCE :
   PHTOEH Pharmacology and Toxicology (Copenhagen).  (Munksgaard International
   Pub., POB 2148, DK-1016 Copenhagen K, Denmark)  V.60-    1987-
   Volume(issue)/page/year: 78,44,1996
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 364 mg/kg/26W-I
TOXIC EFFECTS :
   Kidney, Ureter, Bladder - urine volume increased
   Blood - pigmented or nucleated red blood cells
   Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
   KSRNAM Kiso to Rinsho.  Clinical Report.  (Yubunsha Co., Ltd., 1-5, Kanda
   Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan)  V.1-    1960-
   Volume(issue)/page/year: 31,1465,1997
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Primate - monkey
DOSE/DURATION           : 910 mg/kg/26W-I
TOXIC EFFECTS :
   Gastrointestinal - changes in structure or function of salivary glands
   Gastrointestinal - nausea or vomiting
REFERENCE :
   KSRNAM Kiso to Rinsho.  Clinical Report.  (Yubunsha Co., Ltd., 1-5, Kanda
   Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan)  V.1-    1960-
   Volume(issue)/page/year: 31,1527,1997
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Primate - monkey
DOSE/DURATION           : 448 mg/kg/4W-I
TOXIC EFFECTS :
   Behavioral - coma
   Gastrointestinal - nausea or vomiting
   Related to Chronic Data - death
REFERENCE :
   KSRNAM Kiso to Rinsho.  Clinical Report.  (Yubunsha Co., Ltd., 1-5, Kanda
   Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan)  V.1-    1960-
   Volume(issue)/page/year: 31,1491,1997
 
                            *** END OF RECORD ***