*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : UY5769500
CHEMICAL NAME           : 2-Pyrrolidinone,
                          1-ethyl-4-(2-morpholinoethyl)-3,3-diphenyl-
CAS REGISTRY NUMBER     : 309-29-5
BEILSTEIN REFERENCE NO. : 0628691
LAST UPDATED            : 199612
DATA ITEMS CITED        : 2
MOLECULAR FORMULA       : C24-H30-N2-O2
MOLECULAR WEIGHT        : 378.56
WISWESSER LINE NOTATION : T6N DOTJ A2- DT5NVTJ A2 CR& CR
COMPOUND DESCRIPTOR     : Drug
                          Reproductive Effector
SYNONYMS/TRADE NAMES :
   * Doxapram
   * 1-Ethyl-4-(2-morpholinoethyl)-3,3-diphenyl-2-pyrrolidinone
   * 2-Pyrrolidinone, 1-ethyl-4-(2-(4-morpholinyl)ethyl)-3,3-diphenyl-
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 268 mg/kg
TOXIC EFFECTS :
   Behavioral - altered sleep time (including change in righting reflex)
   Behavioral - somnolence (general depressed activity)
REFERENCE :
   JPPMAB Journal of Pharmacy and Pharmacology.  (Pharmaceutical Soc. of Great
   Britain, 1 Lambeth High St., London SEI 7JN, UK)  V.1-    1949-
   Volume(issue)/page/year: 30,522,1978
 
                          ** REPRODUCTIVE DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Mammal - domestic
DOSE                    : 1800 ug/kg
SEX/DURATION            : female 16 week(s) after conception
TOXIC EFFECTS :
   Reproductive - Effects on Embryo or Fetus - other effects to embryo
REFERENCE :
   BJOGAS British Journal of Obstetrics and Gynaecology.  (Blackwell Scientific
   Pub. Ltd., POB 88, Oxford, UK)  V.82-    1975- Volume(issue)/page/year:
   84,48,1977
 
                            *** END OF RECORD ***