*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : UY8350000
CHEMICAL NAME           : 1H-Pyrrolizine-7-methanol, 2,3-dihydro-1-hydroxy-,
                          (S)-
CAS REGISTRY NUMBER     : 26400-24-8
LAST UPDATED            : 199012
DATA ITEMS CITED        : 11
MOLECULAR FORMULA       : C8-H11-N-O2
MOLECULAR WEIGHT        : 153.20
WISWESSER LINE NOTATION : T55 AN&TJ D1Q FQ -S
COMPOUND DESCRIPTOR     : Mutagen
                          Reproductive Effector
SYNONYMS/TRADE NAMES :
   * Dehydroheliotridine
   * Heliotridine, 3,8-didehydro-
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 92 mg/kg
TOXIC EFFECTS :
   Liver - other changes
REFERENCE :
   CBINA8 Chemico-Biological Interactions.  (Elsevier Scientific Pub. Ireland
   Ltd., POB 85, Limerick, Ireland)  V.1-    1969-  Volume(issue)/page/year:
   12,299,1976
 
                          ** REPRODUCTIVE DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 40 mg/kg
SEX/DURATION            : female 14 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Specific Developmental Abnormalities - Central Nervous System
   Reproductive - Specific Developmental Abnormalities - craniofacial
   (including nose and tongue)
   Reproductive - Specific Developmental Abnormalities - musculoskeletal system
REFERENCE :
   JPTLAS Journal of Pathology.  (John Wiley & Sons, Inc., 605 Third Ave., New
   York, NY 10158) V.97-    1969-  Volume(issue)/page/year: 131,339,1980
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 60 mg/kg
SEX/DURATION            : female 14 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Effects on Embryo or Fetus - fetal death
REFERENCE :
   JPTLAS Journal of Pathology.  (John Wiley & Sons, Inc., 605 Third Ave., New
   York, NY 10158) V.97-    1969-  Volume(issue)/page/year: 131,339,1980
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 30 mg/kg
SEX/DURATION            : female 14 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Effects on Embryo or Fetus - extra-embryonic structures
   (e.g., placenta, umbilical cord)
REFERENCE :
   JPTLAS Journal of Pathology.  (John Wiley & Sons, Inc., 605 Third Ave., New
   York, NY 10158) V.97-    1969-  Volume(issue)/page/year: 131,339,1980
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 40 mg/kg
SEX/DURATION            : female 14 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
   e.g., stunted fetus)
REFERENCE :
   JPTLAS Journal of Pathology.  (John Wiley & Sons, Inc., 605 Third Ave., New
   York, NY 10158) V.97-    1969-  Volume(issue)/page/year: 131,339,1980
 
                            ** MUTATION DATA **
 
TYPE OF TEST            : DNA inhibition
TEST SYSTEM             : Rodent - mouse Kidney
DOSE/DURATION           : 5 mg/L
REFERENCE :
   CBINA8 Chemico-Biological Interactions.  (Elsevier Scientific Pub. Ireland
   Ltd., POB 85, Limerick, Ireland)  V.1-    1969-  Volume(issue)/page/year:
   4,421,1971/1972
 
TYPE OF TEST            : Unscheduled DNA synthesis
TEST SYSTEM             : Mammal - domestic Kidney
DOSE/DURATION           : 10 umol/L
REFERENCE :
   CBINA8 Chemico-Biological Interactions.  (Elsevier Scientific Pub. Ireland
   Ltd., POB 85, Limerick, Ireland)  V.1-    1969-  Volume(issue)/page/year:
   13,243,1976
 
TYPE OF TEST            : DNA inhibition
TEST SYSTEM             : Mammal - domestic Kidney
DOSE/DURATION           : 40 mg/L
REFERENCE :
   CBINA8 Chemico-Biological Interactions.  (Elsevier Scientific Pub. Ireland
   Ltd., POB 85, Limerick, Ireland)  V.1-    1969-  Volume(issue)/page/year:
   10,133,1975
 
TYPE OF TEST            : Mutation test systems - not otherwise specified
TEST SYSTEM             : Mammal - domestic Kidney
DOSE/DURATION           : 10 mg/L
REFERENCE :
   CBINA8 Chemico-Biological Interactions.  (Elsevier Scientific Pub. Ireland
   Ltd., POB 85, Limerick, Ireland)  V.1-    1969-  Volume(issue)/page/year:
   10,133,1975
 
TYPE OF TEST            : Mutation test systems - not otherwise specified
TEST SYSTEM             : Mammal - species unspecified Leukocyte
DOSE/DURATION           : 500 nmol/L
REFERENCE :
   CYTBAI Cytobios. (Faculty Press, 88 Regent St., Cambridge, UK)  V.1- 1969- 
   Volume(issue)/page/year: 3,245,1971
 
TYPE OF TEST            : Cytogenetic analysis
TEST SYSTEM             : Mammal - species unspecified Leukocyte
DOSE/DURATION           : 500 nmol/L
REFERENCE :
   CYTBAI Cytobios. (Faculty Press, 88 Regent St., Cambridge, UK)  V.1- 1969- 
   Volume(issue)/page/year: 3,245,1971
 
                            *** END OF RECORD ***