*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : UY4280000
CHEMICAL NAME           : Pyrrolidinium,
                          1-(3-cyclohexyl-3-hydroxy-3-phenylpropyl)-1-methyl-,
                          chloride
CAS REGISTRY NUMBER     : 3818-88-0
LAST UPDATED            : 199106
DATA ITEMS CITED        : 3
MOLECULAR FORMULA       : C20-H32-N-O.Cl
MOLECULAR WEIGHT        : 337.98
WISWESSER LINE NOTATION : T5KTJ A1 A2XQR&- AL6TJ &Q &G
COMPOUND DESCRIPTOR     : Drug
SYNONYMS/TRADE NAMES :
   * Compound 14045 methochloride
   * (+-)-N-((3-Cyclohexyl-3-hydroxy-3-phenyl)propyl)-N-methylpyrrolidinium  
   chloride
   * 1-(3-Cyclohexyl-3-hydroxy-3-phenylpropyl)-1-methyl-pyrrolidinium chloride
   * 1-Cyclohexyl-1-phenyl-3-pyrrolidino-1-propanol methyl chloride
   * Elorine chloride
   * Lergine chloride
   * Tricoloid chloride
   * Tricyclamol chloride
   * Tricyclamol methochloride
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 984 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   29ZVAB "Handbook of Analytical Toxicology," Sunshine, I., ed., Cleveland,
   OH, Chemical Rubber Co., 1969  Volume(issue)/page/year: -,119,1969
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 395 mg/kg
TOXIC EFFECTS :
   Peripheral Nerve and Sensation - flaccid paralysis without anesthesia
   (usually neuromuscular blockage)
   Lungs, Thorax, or Respiration - other changes
REFERENCE :
   JAPMA8 Journal of the American Pharmaceutical Association, Scientific
   Edition.  (Washington, DC) V.29-49, 1940-60.  For publisher information, see
   JPMSAE.  Volume(issue)/page/year: 43,408,1954
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 11700 ug/kg
TOXIC EFFECTS :
   Peripheral Nerve and Sensation - flaccid paralysis without anesthesia
   (usually neuromuscular blockage)
   Lungs, Thorax, or Respiration - other changes
REFERENCE :
   JAPMA8 Journal of the American Pharmaceutical Association, Scientific
   Edition.  (Washington, DC) V.29-49, 1940-60.  For publisher information, see
   JPMSAE.  Volume(issue)/page/year: 43,408,1954
 
                            *** END OF RECORD ***