*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : UZ1000000
CHEMICAL NAME           : Pyruvic acid, p-hydroxyphenyl-
CAS REGISTRY NUMBER     : 156-39-8
BEILSTEIN REFERENCE NO. : 2691632
REFERENCE               : 4-10-00-03630 (Beilstein Handbook Reference)
LAST UPDATED            : 199803
DATA ITEMS CITED        : 3
MOLECULAR FORMULA       : C9-H8-O4
MOLECULAR WEIGHT        : 180.17
WISWESSER LINE NOTATION : QVV1R DQ
COMPOUND DESCRIPTOR     : Tumorigen
SYNONYMS/TRADE NAMES :
   * Benzenepropanoic acid, 4-hydroxy-alpha-oxo-
   * p-Hydroxyphenylpyruvic acid
   * 3-(p-Hydroxyphenyl)pyruvic acid
   * 3-(4-Hydroxyphenyl)pyruvic acid
   * Testacide
 
                       *** HEALTH HAZARD DATA ***
 
                 ** OTHER MULTIPLE DOSE TOXICITY DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 30 gm/kg/10D-C
TOXIC EFFECTS :
   Biochemical - Metabolism (Intermediary) - amino acids (including renal
   excretion)
REFERENCE :
   JONUAI Journal of Nutrition.  (Subscription Dept., 9650 Rockville Pike,
   Bethesda, MD 20014) V.1-    1928-  Volume(issue)/page/year: 95,535,1968
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 30 gm/kg/10D-C
TOXIC EFFECTS :
   Biochemical - Enzyme inhibition, induction, or change in blood or tissue
   levels - transaminases
   Biochemical - Metabolism (Intermediary) - amino acids (including renal
   excretion)
REFERENCE :
   JONUAI Journal of Nutrition.  (Subscription Dept., 9650 Rockville Pike,
   Bethesda, MD 20014) V.1-    1928-  Volume(issue)/page/year: 95,535,1968
 
                          ** TUMORIGENIC DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 1600 mg/kg/8W-I
TOXIC EFFECTS :
   Tumorigenic - equivocal tumorigenic agent by RTECS criteria
   Kidney, Ureter, Bladder - tumors
REFERENCE :
   VOONAW Voprosy Onkologii.  Problems of Oncology.  For English translation,
   see PONCAU. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR)  V.1-10,
   1928-37; V.1-    1955-  Volume(issue)/page/year: 22(6),47,1976
 
                            *** END OF RECORD ***