*** CHEMICAL IDENTIFICATION *** RTECS NUMBER : UZ1000000 CHEMICAL NAME : Pyruvic acid, p-hydroxyphenyl- CAS REGISTRY NUMBER : 156-39-8 BEILSTEIN REFERENCE NO. : 2691632 REFERENCE : 4-10-00-03630 (Beilstein Handbook Reference) LAST UPDATED : 199803 DATA ITEMS CITED : 3 MOLECULAR FORMULA : C9-H8-O4 MOLECULAR WEIGHT : 180.17 WISWESSER LINE NOTATION : QVV1R DQ COMPOUND DESCRIPTOR : Tumorigen SYNONYMS/TRADE NAMES : * Benzenepropanoic acid, 4-hydroxy-alpha-oxo- * p-Hydroxyphenylpyruvic acid * 3-(p-Hydroxyphenyl)pyruvic acid * 3-(4-Hydroxyphenyl)pyruvic acid * Testacide *** HEALTH HAZARD DATA *** ** OTHER MULTIPLE DOSE TOXICITY DATA ** TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 30 gm/kg/10D-C TOXIC EFFECTS : Biochemical - Metabolism (Intermediary) - amino acids (including renal excretion) REFERENCE : JONUAI Journal of Nutrition. (Subscription Dept., 9650 Rockville Pike, Bethesda, MD 20014) V.1- 1928- Volume(issue)/page/year: 95,535,1968 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 30 gm/kg/10D-C TOXIC EFFECTS : Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - transaminases Biochemical - Metabolism (Intermediary) - amino acids (including renal excretion) REFERENCE : JONUAI Journal of Nutrition. (Subscription Dept., 9650 Rockville Pike, Bethesda, MD 20014) V.1- 1928- Volume(issue)/page/year: 95,535,1968 ** TUMORIGENIC DATA ** TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 1600 mg/kg/8W-I TOXIC EFFECTS : Tumorigenic - equivocal tumorigenic agent by RTECS criteria Kidney, Ureter, Bladder - tumors REFERENCE : VOONAW Voprosy Onkologii. Problems of Oncology. For English translation, see PONCAU. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-10, 1928-37; V.1- 1955- Volume(issue)/page/year: 22(6),47,1976 *** END OF RECORD ***