*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : UZ9850000
CHEMICAL NAME           : Quinaldine, 4-nitro-, 1-oxide
CAS REGISTRY NUMBER     : 4831-62-3
BEILSTEIN REFERENCE NO. : 0187040
REFERENCE               : 4-20-00-03467 (Beilstein Handbook Reference)
LAST UPDATED            : 199612
DATA ITEMS CITED        : 11
MOLECULAR FORMULA       : C10-H8-N2-O3
MOLECULAR WEIGHT        : 204.20
WISWESSER LINE NOTATION : T66 BNJ BO C1 ENW
COMPOUND DESCRIPTOR     : Tumorigen
                          Mutagen
SYNONYMS/TRADE NAMES :
   * 2-Methyl-4-nitroquinoline N-oxide
   * 2-Methyl-4-nitroquinoline-1-oxide
   * 4-Nitroquinaldine-N-oxide
   * Quinoline, 2-methyl-4-nitro, 1-oxide
 
                       *** HEALTH HAZARD DATA ***
 
                          ** TUMORIGENIC DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Administration onto the skin
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 60 mg/kg/10W-I
TOXIC EFFECTS :
   Tumorigenic - equivocal tumorigenic agent by RTECS criteria
   Skin and Appendages - tumors
REFERENCE :
   GANNA2 Gann.  Japanese Journal of Cancer Research.  (Tokyo, Japan)  V.1-75,
   1907-84.  For publisher information, see JJCREP.  Volume(issue)/page/year:
   49,33,1958
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 120 mg/kg/50D-I
TOXIC EFFECTS :
   Tumorigenic - equivocal tumorigenic agent by RTECS criteria
   Tumorigenic - tumors at site of application
REFERENCE :
   BCPCA6 Biochemical Pharmacology.  (Pergamon Press Inc., Maxwell House,
   Fairview Park, Elmsford, NY 10523)  V.1-    1958-  Volume(issue)/page/year:
   16,631,1967
 
                            ** MUTATION DATA **
 
TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Bacteria - Salmonella typhimurium
DOSE/DURATION           : 20 umol/L
REFERENCE :
   CPBTAL Chemical and Pharmaceutical Bulletin.  (Japan Pub. Trading Co., USA,
   1255 Howard St., San Francisco, CA 94103)  V.6-    1958-
   Volume(issue)/page/year: 31,959,1983
 
TYPE OF TEST            : Phage inhibition capacity
TEST SYSTEM             : Bacteria - Escherichia coli
DOSE/DURATION           : 25 umol/L
REFERENCE :
   NATUAS Nature.  (Nature Subscription Dept., POB 1018, Manasguan, NJ 08736)
   V.1-    1869-  Volume(issue)/page/year: 198,195,1963
 
TYPE OF TEST            : Cytogenetic analysis
TEST SYSTEM             : Microorganism - not otherwise specified
DOSE/DURATION           : 195 umol/L
REFERENCE :
   GANNA2 Gann.  Japanese Journal of Cancer Research.  (Tokyo, Japan)  V.1-75,
   1907-84.  For publisher information, see JJCREP.  Volume(issue)/page/year:
   60,155,1969
 
TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Yeast - Saccharomyces cerevisiae
DOSE/DURATION           : 200 ug/L
REFERENCE :
   IGSBAL Igaku to Seibutsugaku.  Medicine and Biology.  (c/o Ogato Igaku
   Kagaku Kenkyusho, 2-3-5 Bakuro-cho, Nihonbashi, Chuo-ku, Tokyo 103, Japan)
   V.1-    1942-  Volume(issue)/page/year: 85,127,1972
 
TYPE OF TEST            : Unscheduled DNA synthesis
TEST SYSTEM             : Human Fibroblast
DOSE/DURATION           : 1 umol/L/90M
REFERENCE :
   IJCNAW International Journal of Cancer.  (International Union Against
   Cancer, 3 rue du Conseil- General, 1205 Geneva, Switzerland)  V.1-    1966-
   Volume(issue)/page/year: 16,284,1975
 
TYPE OF TEST            : Cytogenetic analysis
TEST SYSTEM             : Human Liver
DOSE/DURATION           : 5260 nmol/L
REFERENCE :
   JNCIAM Journal of the National Cancer Institute.  (Washington, DC)  V.1-60,
   1940-78.  For publisher information, see JJIND8.  Volume(issue)/page/year:
   47,367,1971
 
TYPE OF TEST            : DNA damage
TEST SYSTEM             : Rodent - mouse Fibroblast
DOSE/DURATION           : 10 umol/L
REFERENCE :
   CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
   Sts., Philadelphia, PA 19106)  V.1-    1941-  Volume(issue)/page/year:
   35,521,1975
 
TYPE OF TEST            : Unscheduled DNA synthesis
TEST SYSTEM             : Rodent - hamster Cells - not otherwise specified
DOSE/DURATION           : 500 nmol/L
REFERENCE :
   NATUAS Nature.  (Nature Subscription Dept., POB 1018, Manasguan, NJ 08736)
   V.1-    1869-  Volume(issue)/page/year: 229,416,1971

                          *** STATUS IN U.S. ***
 
   EPA GENETOX PROGRAM 1988, Positive/dose response: In vitro UDS-human
   fibroblast

 
                            *** END OF RECORD ***