*** CHEMICAL IDENTIFICATION *** RTECS NUMBER : UZ9850000 CHEMICAL NAME : Quinaldine, 4-nitro-, 1-oxide CAS REGISTRY NUMBER : 4831-62-3 BEILSTEIN REFERENCE NO. : 0187040 REFERENCE : 4-20-00-03467 (Beilstein Handbook Reference) LAST UPDATED : 199612 DATA ITEMS CITED : 11 MOLECULAR FORMULA : C10-H8-N2-O3 MOLECULAR WEIGHT : 204.20 WISWESSER LINE NOTATION : T66 BNJ BO C1 ENW COMPOUND DESCRIPTOR : Tumorigen Mutagen SYNONYMS/TRADE NAMES : * 2-Methyl-4-nitroquinoline N-oxide * 2-Methyl-4-nitroquinoline-1-oxide * 4-Nitroquinaldine-N-oxide * Quinoline, 2-methyl-4-nitro, 1-oxide *** HEALTH HAZARD DATA *** ** TUMORIGENIC DATA ** TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Administration onto the skin SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 60 mg/kg/10W-I TOXIC EFFECTS : Tumorigenic - equivocal tumorigenic agent by RTECS criteria Skin and Appendages - tumors REFERENCE : GANNA2 Gann. Japanese Journal of Cancer Research. (Tokyo, Japan) V.1-75, 1907-84. For publisher information, see JJCREP. Volume(issue)/page/year: 49,33,1958 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 120 mg/kg/50D-I TOXIC EFFECTS : Tumorigenic - equivocal tumorigenic agent by RTECS criteria Tumorigenic - tumors at site of application REFERENCE : BCPCA6 Biochemical Pharmacology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1958- Volume(issue)/page/year: 16,631,1967 ** MUTATION DATA ** TYPE OF TEST : Mutation in microorganisms TEST SYSTEM : Bacteria - Salmonella typhimurium DOSE/DURATION : 20 umol/L REFERENCE : CPBTAL Chemical and Pharmaceutical Bulletin. (Japan Pub. Trading Co., USA, 1255 Howard St., San Francisco, CA 94103) V.6- 1958- Volume(issue)/page/year: 31,959,1983 TYPE OF TEST : Phage inhibition capacity TEST SYSTEM : Bacteria - Escherichia coli DOSE/DURATION : 25 umol/L REFERENCE : NATUAS Nature. (Nature Subscription Dept., POB 1018, Manasguan, NJ 08736) V.1- 1869- Volume(issue)/page/year: 198,195,1963 TYPE OF TEST : Cytogenetic analysis TEST SYSTEM : Microorganism - not otherwise specified DOSE/DURATION : 195 umol/L REFERENCE : GANNA2 Gann. Japanese Journal of Cancer Research. (Tokyo, Japan) V.1-75, 1907-84. For publisher information, see JJCREP. Volume(issue)/page/year: 60,155,1969 TYPE OF TEST : Mutation in microorganisms TEST SYSTEM : Yeast - Saccharomyces cerevisiae DOSE/DURATION : 200 ug/L REFERENCE : IGSBAL Igaku to Seibutsugaku. Medicine and Biology. (c/o Ogato Igaku Kagaku Kenkyusho, 2-3-5 Bakuro-cho, Nihonbashi, Chuo-ku, Tokyo 103, Japan) V.1- 1942- Volume(issue)/page/year: 85,127,1972 TYPE OF TEST : Unscheduled DNA synthesis TEST SYSTEM : Human Fibroblast DOSE/DURATION : 1 umol/L/90M REFERENCE : IJCNAW International Journal of Cancer. (International Union Against Cancer, 3 rue du Conseil- General, 1205 Geneva, Switzerland) V.1- 1966- Volume(issue)/page/year: 16,284,1975 TYPE OF TEST : Cytogenetic analysis TEST SYSTEM : Human Liver DOSE/DURATION : 5260 nmol/L REFERENCE : JNCIAM Journal of the National Cancer Institute. (Washington, DC) V.1-60, 1940-78. For publisher information, see JJIND8. Volume(issue)/page/year: 47,367,1971 TYPE OF TEST : DNA damage TEST SYSTEM : Rodent - mouse Fibroblast DOSE/DURATION : 10 umol/L REFERENCE : CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year: 35,521,1975 TYPE OF TEST : Unscheduled DNA synthesis TEST SYSTEM : Rodent - hamster Cells - not otherwise specified DOSE/DURATION : 500 nmol/L REFERENCE : NATUAS Nature. (Nature Subscription Dept., POB 1018, Manasguan, NJ 08736) V.1- 1869- Volume(issue)/page/year: 229,416,1971 *** STATUS IN U.S. *** EPA GENETOX PROGRAM 1988, Positive/dose response: In vitro UDS-human fibroblast *** END OF RECORD ***