*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : VA1365100
CHEMICAL NAME           : Quinazoline,
                          7-chloro-2-(o-chlorostyryl)-4-(4-(diethylamino)-1-met
                          hylbutylamino)-, diphosphate
CAS REGISTRY NUMBER     : 57942-49-1
LAST UPDATED            : 198909
DATA ITEMS CITED        : 4
MOLECULAR FORMULA       : C25-H30-Cl2-N4.2H3-O4-P
MOLECULAR WEIGHT        : 653.49
COMPOUND DESCRIPTOR     : Drug
SYNONYMS/TRADE NAMES :
   * Aminazoline diphosphate
   *   7-Chloro-2-(o-chlorostyryl)-4-((4-(diethylamino)-1-methylbutyl)amino)qui
     nazoline diphosphate
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 3900 mg/kg
TOXIC EFFECTS :
   Peripheral Nerve and Sensation - flaccid paralysis without anesthesia
   (usually neuromuscular blockage)
   Sense Organs and Special Senses (Olfaction) - change in sensation of smell
   Gastrointestinal - changes in structure or function of salivary glands
REFERENCE :
   PCJOAU Pharmaceutical Chemistry Journal (English Translation).  Translation
   of KHFZAN. (Plenum Pub. Corp., 233 Spring St., New York, NY 10013)  No.1-
   1967-  Volume(issue)/page/year: 21,34,1987
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 450 mg/kg
TOXIC EFFECTS :
   Behavioral - tremor
   Blood - hemorrhage
   Blood - other changes
REFERENCE :
   PCJOAU Pharmaceutical Chemistry Journal (English Translation).  Translation
   of KHFZAN. (Plenum Pub. Corp., 233 Spring St., New York, NY 10013)  No.1-
   1967-  Volume(issue)/page/year: 21,34,1987
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 1200 mg/kg
TOXIC EFFECTS :
   Peripheral Nerve and Sensation - flaccid paralysis without anesthesia
   (usually neuromuscular blockage)
   Sense Organs and Special Senses (Olfaction) - change in sensation of smell
   Behavioral - tremor
REFERENCE :
   PCJOAU Pharmaceutical Chemistry Journal (English Translation).  Translation
   of KHFZAN. (Plenum Pub. Corp., 233 Spring St., New York, NY 10013)  No.1-
   1967-  Volume(issue)/page/year: 21,34,1987
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 130 mg/kg
TOXIC EFFECTS :
   Peripheral Nerve and Sensation - flaccid paralysis without anesthesia
   (usually neuromuscular blockage)
   Sense Organs and Special Senses (Olfaction) - change in sensation of smell
   Behavioral - tremor
REFERENCE :
   PCJOAU Pharmaceutical Chemistry Journal (English Translation).  Translation
   of KHFZAN. (Plenum Pub. Corp., 233 Spring St., New York, NY 10013)  No.1-
   1967-  Volume(issue)/page/year: 21,34,1987
 
                            *** END OF RECORD ***