*** CHEMICAL IDENTIFICATION ***
RTECS NUMBER : VA1399500
CHEMICAL NAME : 2,4(1H,3H)-Quinazolinedione,
3-(3-(4-(m-chlorophenyl)-1-piperazinyl)propyl)-,
monohydrochloride
CAS REGISTRY NUMBER : 525-26-8
LAST UPDATED : 198605
DATA ITEMS CITED : 3
MOLECULAR FORMULA : C21-H23-Cl-N4-O2.Cl-H
MOLECULAR WEIGHT : 435.39
WISWESSER LINE NOTATION : T66 BMVNVJ D3- AT6N DNTJ DR CG &GH
COMPOUND DESCRIPTOR : Drug
SYNONYMS/TRADE NAMES :
* 3-(3-(4-(m-Chlorophenyl)-1-piperazinyl)propyl)-2,4(1H,3H)-quinazolinedio
ne hydrochloride
* Cloperidone hydrochloride
* MA 1337
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 7650 mg/kg
TOXIC EFFECTS :
Lungs, Thorax, or Respiration - respiratory depression
REFERENCE :
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams &
Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10-
Volume(issue)/page/year: 148,151,1965
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 3290 mg/kg
TOXIC EFFECTS :
Lungs, Thorax, or Respiration - respiratory depression
REFERENCE :
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams &
Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10-
Volume(issue)/page/year: 148,151,1965
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 2610 mg/kg
TOXIC EFFECTS :
Lungs, Thorax, or Respiration - respiratory depression
REFERENCE :
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams &
Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10-
Volume(issue)/page/year: 148,151,1965
*** END OF RECORD ***