*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : VA3677000
CHEMICAL NAME           : 4(3H)-Quinazolinone, 2-methyl-
CAS REGISTRY NUMBER     : 1769-24-0
LAST UPDATED            : 199609
DATA ITEMS CITED        : 3
MOLECULAR FORMULA       : C9-H8-N2-O
MOLECULAR WEIGHT        : 160.19
WISWESSER LINE NOTATION : T66 BVM ENJ D1
COMPOUND DESCRIPTOR     : Drug
SYNONYMS/TRADE NAMES :
   * B 101
   * 2-Methyl-chinazolinone(4)
   * 2-Methyl-4-quinazolinone
   * 2-Methylquinazolone
   * 4-Quinazolinol, 2-methyl-
   * 4(1H)-Quinazolinone, 2-methyl-
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 859 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   ARZNAD Arzneimittel-Forschung. Drug Research.  (Editio Cantor Verlag,
   Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.)  V.1-    1951-
   Volume(issue)/page/year: 12,1204,1962
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 592 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   ARZNAD Arzneimittel-Forschung. Drug Research.  (Editio Cantor Verlag,
   Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.)  V.1-    1951-
   Volume(issue)/page/year: 12,1204,1962
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Parenteral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 500 mg/kg
TOXIC EFFECTS :
   Autonomic Nervous System - smooth muscle relaxant (mechanism undefined,
   spasmolytic)
   Behavioral - tremor
   Behavioral - muscle weakness
REFERENCE :
   PCJOAU Pharmaceutical Chemistry Journal (English Translation).  Translation
   of KHFZAN. (Plenum Pub. Corp., 233 Spring St., New York, NY 10013)  No.1-
   1967-  Volume(issue)/page/year: 7,626,1973
 
                            *** END OF RECORD ***