*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : VA9627000
CHEMICAL NAME           : Quinoline, 8-amino-
CAS REGISTRY NUMBER     : 578-66-5
BEILSTEIN REFERENCE NO. : 0114474
REFERENCE               : 5-22-10-00316 (Beilstein Handbook Reference)
LAST UPDATED            : 199710
DATA ITEMS CITED        : 11
MOLECULAR FORMULA       : C9-H8-N2
MOLECULAR WEIGHT        : 144.19
WISWESSER LINE NOTATION : T66 BNJ JQ
COMPOUND DESCRIPTOR     : Drug
                          Mutagen
                          Reproductive Effector
SYNONYMS/TRADE NAMES :
   * 8-Aminoquinoline
   * NC 066
   * 8-Quinolinamine
   * 8-Quinolylamine
   * WR 6920
 
                       *** HEALTH HAZARD DATA ***
 
                          ** REPRODUCTIVE DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 480 mg/kg
SEX/DURATION            : female 6-15 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Maternal Effects - other effects
REFERENCE :
   TOXID9 Toxicologist.  (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway,
   Akron, OH 44311) V.1-    1981-  Volume(issue)/page/year: 3,65,1983
 
                            ** MUTATION DATA **
 
TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Bacteria - Salmonella typhimurium
DOSE/DURATION           : 50 ug/plate
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 39,285,1977
 
TYPE OF TEST            : DNA repair
TEST SYSTEM             : Bacteria - Salmonella typhimurium
DOSE/DURATION           : 350 ug/disc
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 39,285,1977
 
TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Yeast - Saccharomyces cerevisiae
DOSE/DURATION           : 1 mg/L
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 39,285,1977
 
TYPE OF TEST            : Cytogenetic analysis
TEST SYSTEM             : Human Leukocyte
DOSE/DURATION           : 100 umol/L
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 39,285,1977

                          *** STATUS IN U.S. ***
 
   EPA GENETOX PROGRAM 1988, Positive: Histidine reversion-Ames test; S
   cerevisiae-reversion
   
   EPA GENETOX PROGRAM 1988, Negative: S cerevisiae gene conversion
   
   EPA GENETOX PROGRAM 1988, Negative: S cerevisiae-forward mutation; S
   cerevisiae-homozygosis
   
   EPA GENETOX PROGRAM 1988, Inconclusive: D melanogaster Sex-linked lethal
   
   EPA TSCA Section 8(b) CHEMICAL INVENTORY
   
   EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1998

 
                            *** END OF RECORD ***