*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : VA9698000
CHEMICAL NAME           : Quinoline, 8-((3-aminopropyl)amino)-6-methoxy-,
                          dihydrochloride
LAST UPDATED            : 198910
DATA ITEMS CITED        : 2
MOLECULAR FORMULA       : C13-H17-N3-O.2Cl-H
MOLECULAR WEIGHT        : 304.25
WISWESSER LINE NOTATION : T66 BNJ HO1 JM3Z &GH 2
COMPOUND DESCRIPTOR     : Drug
                          Human
SYNONYMS/TRADE NAMES :
   * 8-((3-Aminopropyl)amino)-6-methoxyquinoline dihydrochloride
   * SN 1452
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Human - man
DOSE/DURATION           : 10 mg/kg/6D
TOXIC EFFECTS :
   Gastrointestinal - nausea or vomiting
   Nutritional and Gross Metabolic - body temperature increase
REFERENCE :
   85GLAQ "A Survey of Antimalarial Drugs, 1941-1945," Wiselogle, F.Y., 2
   vols., Ann Arbor, MI, J.W. Edwards, 1946  Volume(issue)/page/year:
   1,414,1946
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 100 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   85GLAQ "A Survey of Antimalarial Drugs, 1941-1945," Wiselogle, F.Y., 2
   vols., Ann Arbor, MI, J.W. Edwards, 1946  Volume(issue)/page/year:
   1,414,1946
 
                            *** END OF RECORD ***