*** CHEMICAL IDENTIFICATION ***
RTECS NUMBER : VB1993500
CHEMICAL NAME : 3-Quinolinecarboxylic acid,
1,4-dihydro-1-cyclopropyl-6,8-difluoro-4-oxo-7-(1-pip
erazinyl)-
CAS REGISTRY NUMBER : 94242-53-2
BEILSTEIN REFERENCE NO. : 3632527
LAST UPDATED : 199612
DATA ITEMS CITED : 3
MOLECULAR FORMULA : C17-H17-F2-N3-O3
MOLECULAR WEIGHT : 349.37
COMPOUND DESCRIPTOR : Drug
SYNONYMS/TRADE NAMES :
* 1-Cyclopropyl-6,8-difluoro-4-oxo-7-(1-piperazinyl)-1,4-dihydro-3-quinoli
necarboxylic acid
* 8-Fluorociprofloxacin
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 186 mg/kg
TOXIC EFFECTS :
Behavioral - altered sleep time (including change in righting reflex)
Behavioral - somnolence (general depressed activity)
REFERENCE :
KJTOEA Korean Journal of Toxicology. (Korean Society of Toxicology, c/o
College of Medicine, Seoul National University, Seoul, 110, S. Korea) V.1-
1985- Volume(issue)/page/year: 8,161,1993
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 1414 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JHTCAD Journal of Heterocyclic Chemistry. (Hetero Corporation, POB 16000 MH,
Tampa, FL 33687) Vol.1- 1964- Volume(issue)/page/year: 26,393,1989
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 126 mg/kg
TOXIC EFFECTS :
Behavioral - altered sleep time (including change in righting reflex)
Behavioral - somnolence (general depressed activity)
REFERENCE :
KJTOEA Korean Journal of Toxicology. (Korean Society of Toxicology, c/o
College of Medicine, Seoul National University, Seoul, 110, S. Korea) V.1-
1985- Volume(issue)/page/year: 8,161,1993
*** END OF RECORD ***