*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : VB1993520
CHEMICAL NAME           : 3-Quinolinecarboxylic acid,
                          1,4-dihydro-1-cyclopropyl-6,8-difluoro-4-oxo-7-
                          (3,4,5,6-tetrahydro-5-methylpyrrolo(3,4-c)pyrrol-2(1H
                          )-yl)-, mono(2-hydroxypropanoate)
CAS REGISTRY NUMBER     : 150433-14-0
LAST UPDATED            : 199409
DATA ITEMS CITED        : 2
MOLECULAR FORMULA       : C20-H19-F2-N3-O3.C3-H6-O3
MOLECULAR WEIGHT        : 477.51
COMPOUND DESCRIPTOR     : Drug
SYNONYMS/TRADE NAMES :
   * KR-10876
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 1056 mg/kg
TOXIC EFFECTS :
   Sense Organs and Special Senses (Eye) - ptosis
   Gastrointestinal - changes in structure or function of salivary glands
   Nutritional and Gross Metabolic - body temperature decrease
REFERENCE :
   APHRDQ Archives of Pharmacal Research.  (Pharmaceutical Soc. of Korea,
   College of Pharmacy, Seoul National Univ., San 56-1, Sinrim-Dong, Kwanak-ku,
   Seoul 151, S. Korea)  V.1-    1978-  Volume(issue)/page/year: 16,6,1993
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 2042 mg/kg
TOXIC EFFECTS :
   Sense Organs and Special Senses (Eye) - ptosis
   Gastrointestinal - changes in structure or function of salivary glands
   Nutritional and Gross Metabolic - body temperature decrease
REFERENCE :
   APHRDQ Archives of Pharmacal Research.  (Pharmaceutical Soc. of Korea,
   College of Pharmacy, Seoul National Univ., San 56-1, Sinrim-Dong, Kwanak-ku,
   Seoul 151, S. Korea)  V.1-    1978-  Volume(issue)/page/year: 16,6,1993
 
                            *** END OF RECORD ***