*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : VB1993785
CHEMICAL NAME           : 3-Quinolinecarboxylic acid,
                          1,4-dihydro-1-cyclopropyl-6-fluoro-5-methyl-7-(3-meth
                          yl- 1-piperazinyl)-4-oxo-
CAS REGISTRY NUMBER     : 119914-60-2
LAST UPDATED            : 199606
DATA ITEMS CITED        : 1
MOLECULAR FORMULA       : C19-H22-F-N3-O3
MOLECULAR WEIGHT        : 359.44
COMPOUND DESCRIPTOR     : Drug
                          Reproductive Effector
SYNONYMS/TRADE NAMES :
   * Grepafloxacin
   * OPC 17116
 
                       *** HEALTH HAZARD DATA ***
 
                          ** REPRODUCTIVE DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rabbit
DOSE                    : 78 mg/kg
SEX/DURATION            : female 6-18 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Maternal Effects - other effects
   Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
   e.g., stunted fetus)
REFERENCE :
   YACHDS Yakuri to Chiryo.  Pharmacology and Therapeutics.  (Raifu Saiensu
   Shuppan K.K., 2-5-13, Yaesu, Chuo-ku, Tokyo 104, Japan)  V.1-    1972-
   Volume(issue)/page/year: 22,4531,1994
 
                            *** END OF RECORD ***