*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : VB4800000
CHEMICAL NAME           : Quinoline, 1,4-dihydro-1-acetoxy-4-hydroxyamino-,
                          acetate (ester)
CAS REGISTRY NUMBER     : 38539-23-0
LAST UPDATED            : 199410
DATA ITEMS CITED        : 3
MOLECULAR FORMULA       : C13-H13-N2-O4
MOLECULAR WEIGHT        : 261.28
WISWESSER LINE NOTATION : T66 BN EHJ BOV1 EMVO1
COMPOUND DESCRIPTOR     : Tumorigen
                          Mutagen
SYNONYMS/TRADE NAMES :
   * 1-Acetoxy-1,4-dihydro-4-(hydroxyamino)quinoline acetate (ester)
   * O,O'-Diacetyl 4-hydroxyaminoquinoline 1-oxide
   * Quinoline, 1-acetoxy-1,4-dihydro-4-hydroxyamino-, acetate (ester)
 
                       *** HEALTH HAZARD DATA ***
 
                          ** TUMORIGENIC DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 5 mg/kg/2W-I
TOXIC EFFECTS :
   Tumorigenic - equivocal tumorigenic agent by RTECS criteria
   Tumorigenic - tumors at site of application
REFERENCE :
   PSEBAA Proceedings of the Society for Experimental Biology and Medicine.
   (Academic Press, Inc., 1 E. First St., Duluth, MN 55802)  V.1-    1903/04-
   Volume(issue)/page/year: 136,1206,1971
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 30 mg/kg/4W-I
TOXIC EFFECTS :
   Tumorigenic - neoplastic by RTECS criteria
   Tumorigenic - tumors at site of application
REFERENCE :
   PSEBAA Proceedings of the Society for Experimental Biology and Medicine.
   (Academic Press, Inc., 1 E. First St., Duluth, MN 55802)  V.1-    1903/04-
   Volume(issue)/page/year: 136,1206,1971
 
                            ** MUTATION DATA **
 
TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Yeast - Saccharomyces cerevisiae
DOSE/DURATION           : 50 mg/L
REFERENCE :
   IGSBAL Igaku to Seibutsugaku.  Medicine and Biology.  (c/o Ogato Igaku
   Kagaku Kenkyusho, 2-3-5 Bakuro-cho, Nihonbashi, Chuo-ku, Tokyo 103, Japan)
   V.1-    1942-  Volume(issue)/page/year: 85,127,1972
 
                            *** END OF RECORD ***