*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : VC0308000
CHEMICAL NAME           : 4-Quinolinemethanol,
                          2,8-bis(trifluoromethyl)-alpha-2-piperidinyl-,
                          monohydrochloride, (R*,S*)-, (+-)-
CAS REGISTRY NUMBER     : 51773-92-3
LAST UPDATED            : 199603
DATA ITEMS CITED        : 6
MOLECULAR FORMULA       : C17-H16-F6-N2-O.Cl-H
MOLECULAR WEIGHT        : 414.81
WISWESSER LINE NOTATION : T66 BNJ CXFFF EYQ- BT6MTJ& JXFFF &GH
COMPOUND DESCRIPTOR     : Drug
                          Human
SYNONYMS/TRADE NAMES :
   *   dl-Erythro-alpha-(2-piperidyl)-2,8-bis(trifluoromethyl)-4-quinolinemetha
     nol hydrochloride
   * Mefloquine hydrochloride
   * WR 14249
   * WR 142490
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Human - man
DOSE/DURATION           : 96 mg/kg/52D-I
TOXIC EFFECTS :
   Behavioral - hallucinations, distorted perceptions
   Behavioral - excitement
   Behavioral - aggression
REFERENCE :
   AIMDAP Archives of Internal Medicine.  (AMA, 535 N. Dearborn St., Chicago,
   IL 60610)  V.1-    1908-  Volume(issue)/page/year: 154,2360,1994
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Human - woman
DOSE/DURATION           : 15 mg/kg/3W-I
TOXIC EFFECTS :
   Behavioral - convulsions or effect on seizure threshold
   Behavioral - coma
REFERENCE :
   MJAUAJ Medical Journal of Australia.  (Australasian Medical Pub. Co. Ltd.,
   71-79 Arundel St., Glebe, N.S.W., Australia)  V.1-    1914-
   Volume(issue)/page/year: 161,453,1994
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Human - man
DOSE/DURATION           : 11 mg/kg/2W-I
TOXIC EFFECTS :
   Behavioral - convulsions or effect on seizure threshold
REFERENCE :
   AIMEAS Annals of Internal Medicine.  (American College of Physicians, 4200
   Pine St., Philadelphia, PA 19104)  V.1-    1927-  Volume(issue)/page/year:
   114,994,1991
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Human - man
DOSE/DURATION           : 18 mg/kg/5W-I
TOXIC EFFECTS :
   Peripheral Nerve and Sensation - paresthesis
   Behavioral - general anesthetic
REFERENCE :
   AIMEAS Annals of Internal Medicine.  (American College of Physicians, 4200
   Pine St., Philadelphia, PA 19104)  V.1-    1927-  Volume(issue)/page/year:
   117,1058,1992
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 880 mg/kg
TOXIC EFFECTS :
   Gastrointestinal - nausea or vomiting
   Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
   ACTRAQ Acta Tropica.  (Schwabe & Co., Steintorstr. 13, CH-4010 Basel,
   Switzerland)  V.1-    1944-  Volume(issue)/page/year: 37,232,1980
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 130 mg/kg
TOXIC EFFECTS :
   Gastrointestinal - nausea or vomiting
   Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
   ACTRAQ Acta Tropica.  (Schwabe & Co., Steintorstr. 13, CH-4010 Basel,
   Switzerland)  V.1-    1944-  Volume(issue)/page/year: 37,232,1980
 
                            *** END OF RECORD ***