*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : VB2356100
CHEMICAL NAME           : Quinoline,
                          7-chloro-4-((4-(diethylamino)cyclohexyl)amino)-
CAS REGISTRY NUMBER     : 32571-44-1
BEILSTEIN REFERENCE NO. : 0090121
REFERENCE               : 4-22-00-04642 (Beilstein Handbook Reference)
LAST UPDATED            : 199612
DATA ITEMS CITED        : 3
MOLECULAR FORMULA       : C19-H26-Cl-N3
MOLECULAR WEIGHT        : 331.93
COMPOUND DESCRIPTOR     : Drug
SYNONYMS/TRADE NAMES :
   * 7-Chloro-4-((4-(diethylamino)cyclohexyl)amino)quinoline
   * 1,4-Cyclohexanediamine, N'-(7-chloro-4-quinolinyl)-N,N-diethyl-
   * SN 14477
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 67 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   85GLAQ "A Survey of Antimalarial Drugs, 1941-1945," Wiselogle, F.Y., 2
   vols., Ann Arbor, MI, J.W. Edwards, 1946  Volume(issue)/page/year:
   1,405,1946
 
                 ** OTHER MULTIPLE DOSE TOXICITY DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Mammal - dog
DOSE/DURATION           : 650 mg/kg/10D-I
TOXIC EFFECTS :
   Behavioral - tremor
   Gastrointestinal - nausea or vomiting
REFERENCE :
   85GLAQ "A Survey of Antimalarial Drugs, 1941-1945," Wiselogle, F.Y., 2
   vols., Ann Arbor, MI, J.W. Edwards, 1946  Volume(issue)/page/year:
   1,405,1946
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Unreported
SPECIES OBSERVED        : Primate - monkey
DOSE/DURATION           : 400 mg/kg/4D-I
TOXIC EFFECTS :
   Behavioral - food intake (animal)
   Behavioral - muscle weakness
   Related to Chronic Data - death
REFERENCE :
   85GLAQ "A Survey of Antimalarial Drugs, 1941-1945," Wiselogle, F.Y., 2
   vols., Ann Arbor, MI, J.W. Edwards, 1946  Volume(issue)/page/year:
   1,405,1946
 
                            *** END OF RECORD ***