*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : VB2806500
CHEMICAL NAME           : Quinoline,
                          4-((3-((2-chloroethyl)ethylamino)propyl)amino)-6-meth
                          oxy-, dihydrochloride
CAS REGISTRY NUMBER     : 13441-95-7
LAST UPDATED            : 199410
DATA ITEMS CITED        : 3
MOLECULAR FORMULA       : C17-H24-Cl-N3-O.2Cl-H
MOLECULAR WEIGHT        : 394.81
WISWESSER LINE NOTATION : T66 BNJ EM3N2&2G HO1 &GH 2
COMPOUND DESCRIPTOR     : Drug
                          Mutagen
SYNONYMS/TRADE NAMES :
   * 4-((3-((2-Chloroethyl)ethylamino)propyl)amino)-6-methoxyquinoline  
   dihydrochloride
   * ICR-174
   * 1,3-Propanediamine, N-(2-chloroethyl)-N-ethyl-N'-(6-methoxy-4-quinolyl)-, 
    dihydrochloride
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD20 - Lethal Dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 1651 ug/kg
TOXIC EFFECTS :
   Tumorigenic - active as anti-cancer agent
REFERENCE :
   JMCMAR Journal of Medicinal Chemistry.  (American Chemical Soc.,
   Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC
   20037)  V.6-    1963-  Volume(issue)/page/year: 15,739,1972
 
                            ** MUTATION DATA **
 
TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Mold - Neurospora crassa
DOSE/DURATION           : 1 mmol/L
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 4,265,1967

                          *** STATUS IN U.S. ***
 
   EPA GENETOX PROGRAM 1988, Positive: N crassa-reversion

 
                            *** END OF RECORD ***