*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : VC3543500
CHEMICAL NAME           : Quinolinium,
                          6-(dimethylamino)-2-(2-(2,5-dimethyl-1-phenylpyrrol-3
                          -yl)vinyl)-1-methyl-, salt with
                          4,4'-methylenebis(3-hydroxy-2-naphthoic acid) (2:1)
CAS REGISTRY NUMBER     : 3546-41-6
LAST UPDATED            : 199512
DATA ITEMS CITED        : 11
MOLECULAR FORMULA       : C75-H70-N6-O6
MOLECULAR WEIGHT        : 1151.51
WISWESSER LINE NOTATION : T66 BKJ B1 HN1&1 C1U1- CT5NJ AR& B1 E1 &L66J CQ DVO
                          B1- BL66J CQ DVO
COMPOUND DESCRIPTOR     : Drug
                          Mutagen
SYNONYMS/TRADE NAMES :
   * Alnoxin
   * Altolat
   * Molevac
   * Neo-oxypate
   * Pamovin
   * Pirvinium pamoate
   * Povan
   * Povanyl
   * Pyrcon
   * Pyrvinium embonate
   * Pyrvinium 4,4'-methylenebis(3-hydroxynaphthalene-2-carboxylate)
   * Pyrvinium pamoate
   * SN-4395
   * Tolapin
   * TRU
   * Vanquin
   * Viprynium embonate
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 5 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   OYYAA2 Oyo Yakuri.  Pharmacometrics.  (Oyo Yakuri Kenkyukai, CPO Box 180,
   Sendai 980-91, Japan) V.1-    1967-  Volume(issue)/page/year: 5,305,1971
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 200 mg/kg
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
   Behavioral - tremor
REFERENCE :
   ARZNAD Arzneimittel-Forschung. Drug Research.  (Editio Cantor Verlag,
   Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.)  V.1-    1951-
   Volume(issue)/page/year: 15,1349,1965
 
                 ** OTHER MULTIPLE DOSE TOXICITY DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 15 gm/kg/30D-C
TOXIC EFFECTS :
   Endocrine - other changes
   Related to Chronic Data - death
   Related to Chronic Data - changes in testicular weight
REFERENCE :
   OYYAA2 Oyo Yakuri.  Pharmacometrics.  (Oyo Yakuri Kenkyukai, CPO Box 180,
   Sendai 980-91, Japan) V.1-    1967-  Volume(issue)/page/year: 5,313,1971
 
                            ** MUTATION DATA **
 
TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Bacteria - Salmonella typhimurium
DOSE/DURATION           : 1 ug/plate
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 222,161,1989
 
TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Bacteria - Salmonella typhimurium
DOSE/DURATION           : 2500 ng/plate
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 117,79,1983
 
TYPE OF TEST            : DNA repair
TEST SYSTEM             : Bacteria - Escherichia coli
DOSE/DURATION           : 5 mg/disc
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 188,111,1987
 
TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Yeast - Saccharomyces cerevisiae
DOSE/DURATION           : 200 umol/L
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 187,79,1987
 
TYPE OF TEST            : Gene conversion and mitotic recombination
TEST SYSTEM             : Yeast - Saccharomyces cerevisiae
DOSE/DURATION           : 400 umol/L
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 187,79,1987

         *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***

NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
   NOHS - National Occupational Hazard Survey (1974)
     NOHS Hazard Code - 81965
       No. of Facilities: 805 (estimated)
       No. of Industries: 1
       No. of Occupations: 1
       No. of Employees: 805 (estimated)
   
   NOES - National Occupational Exposure Survey (1983)
     NOES Hazard Code - 81965
       No. of Facilities: 19 (estimated)
       No. of Industries: 1
       No. of Occupations: 2
       No. of Employees: 774 (estimated)
       No. of Female Employees: 337 (estimated)

                          *** STATUS IN U.S. ***
 
   EPA GENETOX PROGRAM 1988, Positive: Histidine reversion-Ames test

 
                            *** END OF RECORD ***