*** CHEMICAL IDENTIFICATION *** RTECS NUMBER : VH0450000 CHEMICAL NAME : Resorcinol, 4-chloro- CAS REGISTRY NUMBER : 95-88-5 BEILSTEIN REFERENCE NO. : 2042864 REFERENCE : 4-06-00-05684 (Beilstein Handbook Reference) LAST UPDATED : 199710 DATA ITEMS CITED : 9 MOLECULAR FORMULA : C6-H5-Cl-O2 MOLECULAR WEIGHT : 144.56 WISWESSER LINE NOTATION : QR CQ DG COMPOUND DESCRIPTOR : Mutagen Reproductive Effector Primary Irritant SYNONYMS/TRADE NAMES : * 1,3-Benzenediol, 4-chloro- * 4-Chlororesorcin * p-Chlororesorcinol * 4-Chlororesorcinol * 6-Chlororesorcinol * C.I. 76510 * 2,4-Dihydroxychlorobenzene *** HEALTH HAZARD DATA *** ** SKIN/EYE IRRITATION DATA ** TYPE OF TEST : Standard Draize test ROUTE OF EXPOSURE : Administration into the eye SPECIES OBSERVED : Rodent - rabbit DOSE/DURATION : 5% REACTION SEVERITY : Mild REFERENCE : JAPMA8 Journal of the American Pharmaceutical Association, Scientific Edition. (Washington, DC) V.29-49, 1940-60. For publisher information, see JPMSAE. Volume(issue)/page/year: 46,185,1957 ** ACUTE TOXICITY DATA ** TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 369 mg/kg TOXIC EFFECTS : Behavioral - somnolence (general depressed activity) Behavioral - ataxia Skin and Appendages - hair REFERENCE : FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For publisher information, see FCTOD7. Volume(issue)/page/year: 15,607,1977 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 195 mg/kg TOXIC EFFECTS : Behavioral - somnolence (general depressed activity) Behavioral - tremor Behavioral - ataxia REFERENCE : JAPMA8 Journal of the American Pharmaceutical Association, Scientific Edition. (Washington, DC) V.29-49, 1940-60. For publisher information, see JPMSAE. Volume(issue)/page/year: 46,185,1957 ** REPRODUCTIVE DATA ** TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE : 2 gm/kg SEX/DURATION : female 6-15 day(s) after conception TOXIC EFFECTS : Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants) REFERENCE : JACTDZ Journal of the American College of Toxicology. (Mary Ann Liebert, Inc., 1651 Third Ave., New York, NY 10128) V.1-12, 1982-1993. Discontinued. Volume(issue)/page/year: 2(4),325,1983 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X7016 No. of Facilities: 2984 (estimated) No. of Industries: 3 No. of Occupations: 3 No. of Employees: 26087 (estimated) No. of Female Employees: 19986 (estimated) *** STATUS IN U.S. *** EPA GENETOX PROGRAM 1988, Negative: N crassa-aneuploidy EPA GENETOX PROGRAM 1988, Inconclusive: Mammalian micronucleus EPA TSCA Section 8(b) CHEMICAL INVENTORY EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1998 *** END OF RECORD ***