*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : VH0450000
CHEMICAL NAME           : Resorcinol, 4-chloro-
CAS REGISTRY NUMBER     : 95-88-5
BEILSTEIN REFERENCE NO. : 2042864
REFERENCE               : 4-06-00-05684 (Beilstein Handbook Reference)
LAST UPDATED            : 199710
DATA ITEMS CITED        : 9
MOLECULAR FORMULA       : C6-H5-Cl-O2
MOLECULAR WEIGHT        : 144.56
WISWESSER LINE NOTATION : QR CQ DG
COMPOUND DESCRIPTOR     : Mutagen
                          Reproductive Effector
                          Primary Irritant
SYNONYMS/TRADE NAMES :
   * 1,3-Benzenediol, 4-chloro-
   * 4-Chlororesorcin
   * p-Chlororesorcinol
   * 4-Chlororesorcinol
   * 6-Chlororesorcinol
   * C.I. 76510
   * 2,4-Dihydroxychlorobenzene
 
                       *** HEALTH HAZARD DATA ***
 
                      ** SKIN/EYE IRRITATION DATA **
 
TYPE OF TEST            : Standard Draize test
ROUTE OF EXPOSURE       : Administration into the eye
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : 5%
REACTION SEVERITY       : Mild
REFERENCE :
   JAPMA8 Journal of the American Pharmaceutical Association, Scientific
   Edition.  (Washington, DC) V.29-49, 1940-60.  For publisher information, see
   JPMSAE.  Volume(issue)/page/year: 46,185,1957
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 369 mg/kg
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
   Behavioral - ataxia
   Skin and Appendages - hair
REFERENCE :
   FCTXAV Food and Cosmetics Toxicology.  (London, UK)  V.1-19, 1963-81.  For
   publisher information, see FCTOD7.  Volume(issue)/page/year: 15,607,1977
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 195 mg/kg
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
   Behavioral - tremor
   Behavioral - ataxia
REFERENCE :
   JAPMA8 Journal of the American Pharmaceutical Association, Scientific
   Edition.  (Washington, DC) V.29-49, 1940-60.  For publisher information, see
   JPMSAE.  Volume(issue)/page/year: 46,185,1957
 
                          ** REPRODUCTIVE DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 2 gm/kg
SEX/DURATION            : female 6-15 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
   resorbed implants per total number of implants)
REFERENCE :
   JACTDZ Journal of the American College of Toxicology.  (Mary Ann Liebert,
   Inc., 1651 Third Ave., New York, NY 10128)  V.1-12, 1982-1993. Discontinued.
    Volume(issue)/page/year: 2(4),325,1983

         *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***

NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
   NOES - National Occupational Exposure Survey (1983)
     NOES Hazard Code - X7016
       No. of Facilities: 2984 (estimated)
       No. of Industries: 3
       No. of Occupations: 3
       No. of Employees: 26087 (estimated)
       No. of Female Employees: 19986 (estimated)

                          *** STATUS IN U.S. ***
 
   EPA GENETOX PROGRAM 1988, Negative: N crassa-aneuploidy
   
   EPA GENETOX PROGRAM 1988, Inconclusive: Mammalian micronucleus
   
   EPA TSCA Section 8(b) CHEMICAL INVENTORY
   
   EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1998

 
                            *** END OF RECORD ***