*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : VH4725000
CHEMICAL NAME           : Restrictocin
CAS REGISTRY NUMBER     : 1406-72-0
LAST UPDATED            : 199606
DATA ITEMS CITED        : 5
SYNONYMS/TRADE NAMES :
   * NSC-53398
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 30 mg/kg
TOXIC EFFECTS :
   Gastrointestinal - ulceration or bleeding from small intestine
   Gastrointestinal - ulceration or bleeding from large intestine
REFERENCE :
   NCINS* National Cancer Institute Report.  (Bethesda, MD 20014)
   Volume(issue)/page/year: -,9,1964
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : >400 mg/kg
TOXIC EFFECTS :
   Gastrointestinal - other changes
   Blood - hemorrhage
REFERENCE :
   NCINS* National Cancer Institute Report.  (Bethesda, MD 20014)
   Volume(issue)/page/year: -,9,1964
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 20 mg/kg
TOXIC EFFECTS :
   Gastrointestinal - ulceration or bleeding from small intestine
   Gastrointestinal - ulceration or bleeding from large intestine
REFERENCE :
   NCINS* National Cancer Institute Report.  (Bethesda, MD 20014)
   Volume(issue)/page/year: -,9,1964
 
                 ** OTHER MULTIPLE DOSE TOXICITY DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Mammal - dog
DOSE/DURATION           : 2240 ug/kg/28D-I
TOXIC EFFECTS :
   Behavioral - convulsions or effect on seizure threshold
   Liver - other changes
   Kidney, Ureter, Bladder - changes in tubules (including acute renal failure,
   acute tubular necrosis)
REFERENCE :
   NCINS* National Cancer Institute Report.  (Bethesda, MD 20014)
   Volume(issue)/page/year: -,9,1964
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Unreported
SPECIES OBSERVED        : Primate - monkey
DOSE/DURATION           : 8960 ug/kg/28D-I
TOXIC EFFECTS :
   Liver - fatty liver degeneration
   Kidney, Ureter, Bladder - changes in tubules (including acute renal failure,
   acute tubular necrosis)
   Blood - changes in leukocyte (WBC) count
REFERENCE :
   NCINS* National Cancer Institute Report.  (Bethesda, MD 20014)
   Volume(issue)/page/year: -,9,1964
 
                            *** END OF RECORD ***