*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : VH6413000
CHEMICAL NAME           : Retinamide, N-(2-hydroxyethyl)-
CAS REGISTRY NUMBER     : 33631-47-9
BEILSTEIN REFERENCE NO. : 2161307
LAST UPDATED            : 199612
DATA ITEMS CITED        : 3
MOLECULAR FORMULA       : C22-H33-N-O2
MOLECULAR WEIGHT        : 343.56
WISWESSER LINE NOTATION : L6UTJ A1 B1U1Y1&U2U1Y1&U1VM2Q C1 C1
COMPOUND DESCRIPTOR     : Reproductive Effector
SYNONYMS/TRADE NAMES :
   * HER
   * 2-Hydroxyethyl retinamide
   * N-(2-Hydroxyethyl)retinamide
   * Retinoic acid 2-hydroxyethylamide
   * Ro 8-4969
 
                       *** HEALTH HAZARD DATA ***
 
                 ** OTHER MULTIPLE DOSE TOXICITY DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 2092 mg/kg/21D-I
TOXIC EFFECTS :
   Blood - changes in other cell count (unspecified)
   Blood - changes in erythrocyte (RBC) count
REFERENCE :
   JJIND8 JNCI, Journal of the National Cancer Institute.  (Washington, DC)
   V.61-79, 1978-87. For publisher information, see JNCIEQ.
   Volume(issue)/page/year: 63,1359,1979
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 2092 mg/kg/21D-I
TOXIC EFFECTS :
   Blood - changes in other cell count (unspecified)
   Blood - changes in erythrocyte (RBC) count
   Related to Chronic Data - death
REFERENCE :
   JJIND8 JNCI, Journal of the National Cancer Institute.  (Washington, DC)
   V.61-79, 1978-87. For publisher information, see JNCIEQ.
   Volume(issue)/page/year: 63,1359,1979
 
                          ** REPRODUCTIVE DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - hamster
DOSE                    : 4025 mg/kg
SEX/DURATION            : male 25 week(s) pre-mating
TOXIC EFFECTS :
   Reproductive - Paternal Effects - testes, epididymis, sperm duct
REFERENCE :
   TXCYAC Toxicology.  (Elsevier Scientific Pub. Ireland, Ltd., POB 85,
   Limerick, Ireland) V.1-    1973-  Volume(issue)/page/year: 17,343,1980
 
                            *** END OF RECORD ***