*** CHEMICAL IDENTIFICATION *** RTECS NUMBER : VH7175000 CHEMICAL NAME : Retronecine CAS REGISTRY NUMBER : 480-85-3 LAST UPDATED : 199009 DATA ITEMS CITED : 2 MOLECULAR FORMULA : C8-H13-N-O2 MOLECULAR WEIGHT : 155.22 WISWESSER LINE NOTATION : T55 AN CUTJ D1Q FQ COMPOUND DESCRIPTOR : Drug Natural Product SYNONYMS/TRADE NAMES : * 1H-Pyrrolizine-7-methanol, 2,3,5,7a-tetrahydro-1-hydroxy-, (1R-trans)- * Retronecin * (+)-Retronecine *** HEALTH HAZARD DATA *** ** ACUTE TOXICITY DATA ** TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 1311 mg/kg TOXIC EFFECTS : Lungs, Thorax, or Respiration - acute pulmonary edema Liver - hepatitis (hepatocellular necrosis), diffuse Blood - lymphoma, including Hodgkin's disease REFERENCE : RETOAE Research Today. (Indianapolis, IN) V.1-16, 1944-60. Discontinued. Volume(issue)/page/year: 5,53,1949 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 634 mg/kg TOXIC EFFECTS : Behavioral - convulsions or effect on seizure threshold REFERENCE : JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 75,78,1942 *** END OF RECORD ***