*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : VI1800000
CHEMICAL NAME           : Rhizoxin
CAS REGISTRY NUMBER     : 90996-54-6
BEILSTEIN REFERENCE NO. : 5692896
LAST UPDATED            : 199612
DATA ITEMS CITED        : 4
MOLECULAR FORMULA       : C35-H47-N-O9
MOLECULAR WEIGHT        : 625.83
COMPOUND DESCRIPTOR     : Drug
                          Mutagen
                          Natural Product
SYNONYMS/TRADE NAMES :
   * Antibiotic WF-1360
   * WF-1360
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 2500 ug/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   JANTAJ Journal of Antibiotics.  (Japan Antibiotics Research Assoc., 2-20-8
   Kamiosaki, Shinagawa-ku, Tokyo, 141, Japan)  V.2-5, 1948-52;  V.21- 1968-
   Volume(issue)/page/year: 39,762,1986
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 3700 ug/kg
TOXIC EFFECTS :
   Behavioral - changes in motor activity (specific assay)
   Behavioral - ataxia
   Skin and Appendages - hair
REFERENCE :
   ANONE2 Annals of Oncology.  (European Society for Medical Oncology,
   Distributed by Kluwer Academic Publishers, Postbus 17, 3300 AA Dordrecht,
   Netherlands)  V.1-    1990-  Volume(issue)/page/year: 3,755,1992
 
                 ** OTHER MULTIPLE DOSE TOXICITY DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 2500 ug/kg/10D-I
TOXIC EFFECTS :
   Blood - changes in erythrocyte (RBC) count
   Blood - changes in leukocyte (WBC) count
REFERENCE :
   ANONE2 Annals of Oncology.  (European Society for Medical Oncology,
   Distributed by Kluwer Academic Publishers, Postbus 17, 3300 AA Dordrecht,
   Netherlands)  V.1-    1990-  Volume(issue)/page/year: 3,755,1992
 
                            ** MUTATION DATA **
 
TYPE OF TEST            : DNA inhibition
TEST SYSTEM             : Non-mammalian species Embryo
DOSE/DURATION           : 16 umol/L
REFERENCE :
   JANTAJ Journal of Antibiotics.  (Japan Antibiotics Research Assoc., 2-20-8
   Kamiosaki, Shinagawa-ku, Tokyo, 141, Japan)  V.2-5, 1948-52;  V.21- 1968-
   Volume(issue)/page/year: 40,66,1987
 
                            *** END OF RECORD ***