*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : VO1602000
CHEMICAL NAME           : Salicylic acid, p-amino-, 2-(diethylamino)ethyl
                          ester, hydrochloride
CAS REGISTRY NUMBER     : 551-36-0
LAST UPDATED            : 199109
DATA ITEMS CITED        : 7
MOLECULAR FORMULA       : C13-H20-N2-O3.Cl-H
MOLECULAR WEIGHT        : 288.81
WISWESSER LINE NOTATION : ZR CQ DVO2N2&2 &GH
COMPOUND DESCRIPTOR     : Drug
SYNONYMS/TRADE NAMES :
   * 4-Amino-2-hydroxybenzoic acid, 2-(diethylamino)ethyl ester, hydrochloride
   * p-Aminosalicylic acid, 2-(diethylamino)ethyl ester hydrochloride
   * 4-Aminosalicylic acid 2-(diethylamino)ethyl ester hydrochloride
   * p-Aminosalicylsaeurediaethylaminoaethylester-chlorhydrat
   * C 4201
   * HCl salz des p-amino-salicylsaeure-diaethylaminoaethylester
   * Oxyprocain hydrochloride
   * Salicylic acid, 4-amino-, 2-(diethylamino)ethyl ester, hydrochloride
   * WIN 2022
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 130 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   ZENBAX Zeitschrift fuer Naturforschung, Teil B: Anorganische Chemie,
   Organische Chemie, Biochemie, Biophysik, Biologie.  (Tuebingen, Fed. Rep.
   Ger.)  V.2B-27B, 1947-1972.  For publisher information, see ZNCBDA.
   Volume(issue)/page/year: 6B,183,1951
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 140 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   ARZNAD Arzneimittel-Forschung. Drug Research.  (Editio Cantor Verlag,
   Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.)  V.1-    1951-
   Volume(issue)/page/year: 8,181,1958
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 36 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   ARZNAD Arzneimittel-Forschung. Drug Research.  (Editio Cantor Verlag,
   Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.)  V.1-    1951-
   Volume(issue)/page/year: 1,154,1951
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 135 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   ZENBAX Zeitschrift fuer Naturforschung, Teil B: Anorganische Chemie,
   Organische Chemie, Biochemie, Biophysik, Biologie.  (Tuebingen, Fed. Rep.
   Ger.)  V.2B-27B, 1947-1972.  For publisher information, see ZNCBDA.
   Volume(issue)/page/year: 6B,183,1951
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 115 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   ARZNAD Arzneimittel-Forschung. Drug Research.  (Editio Cantor Verlag,
   Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.)  V.1-    1951-
   Volume(issue)/page/year: 1,154,1951
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 282 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   ARZNAD Arzneimittel-Forschung. Drug Research.  (Editio Cantor Verlag,
   Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.)  V.1-    1951-
   Volume(issue)/page/year: 8,708,1958
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 37 mg/kg
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
   Behavioral - convulsions or effect on seizure threshold
   Lungs, Thorax, or Respiration - other changes
REFERENCE :
   JPETAB Journal of Pharmacology and Experimental Therapeutics.  (Williams &
   Wilkins Co., 428 E. Preston St., Baltimore, MD 21202)  V.1-    1909/10-
   Volume(issue)/page/year: 104,40,1952
 
                            *** END OF RECORD ***